查詢結果分析
相關文獻
- Applications of Highly Sulfated Cyclodextrins for Enantiomeric Separation by Capillary Electrophoresis
- 反轉電滲流毛細管電泳與高效率液相層析分離四種Cinnamic Acid衍生物之比較
- 毛細管電泳在農藥主成份分析之應用
- Determination of Adenosine and Cordycepin Contents in Cultivated Cordyceps by Micellar Electrokinetic Capillary Chromatography
- Applications of Capillary Electrophoresis in Pharmaceutical Drug Analysis
- Determination of Polar Constituents in Scrophulariae Radix by Micellar Electrokinetic Capillary Chromatography
- 利用毛細管電泳鑑別燕窩
- 毛細管電泳在蜂王漿蛋白質分析上之應用
- 毛細管電泳之應用
- 毛細管電泳於組合化學中反應最佳化之應用
頁籤選單縮合
題名 | Applications of Highly Sulfated Cyclodextrins for Enantiomeric Separation by Capillary Electrophoresis |
---|---|
作者姓名(中文) | 陳富泰; | 書刊名 | Journal of the Chinese Chemical Society |
卷期 | 46:5 1999.10[民88.10] |
頁次 | 頁847-860 |
分類號 | 346 |
關鍵詞 | 毛細管電泳; 低糖類; Enantiomeric separation; Highly sulfated cyclodextrins; Capillary electrophoresis; |
語文 | 英文(English) |
英文摘要 | Separation of enantiomeric pairs of compounds by capillary electrophoresis (CE) was performed using highly sulfated α -, β - and γ -cyclodextrins (HS-CDs). CE analysis of the HS-CDs using indirect absorbance detection showed that the new class of chiral selectors has substantially higher degrees of sulfation and narrower heterogeneity than those used in previous reports. Elemental analyses showed that the average number of sulfate groups per cyclodextrin was 11, 12, and 13, for HS- α, β and γ CD, respectively. Our earlier �C C NMR data of HS-CDs were consistent with the structural assignment of complete sulfation at the C-6 primary hydroxyl groups, greater than 70% sulfation at the C-2 secondary hydroxyls and absence of substitution at the C-3 hydroxyls. CE-based chiral separations were performed using a generalized procedure with phosphate buffer (pH 2.5) containing 5% (w/v) HS-CD in a 50 μ m I.D. × 31 cm (total length) fused silica capillary. Quantitation of enantiomeric impurity of less than 1% was demonstrated for pseudoephedrine and phenylpropanolamine. The HS- α, β and γ CD complement each other by exhibiting different chiral selectivity. The combination of HS- α, β and γ CD resolved more than 140 chiral compounds of neutral, acidic and basic drugs with very different structural features. The HS-CDs were synthesized under conditions of controlled sulfation to produce chiral reagents with consistent composition, making them excellent chiral selectors for capillary electrophoretic analysis of enantiomeric impurities. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。