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頁籤選單縮合
題名 | The Processing of Metabolized Low Density Lipoproteins in Foam Cells Generates Superoxide Anions=泡沫細胞中低密度脂蛋白之代謝產生超氧化離子 |
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作者 | 黃國華; 陳忠信; 羅彗如; 楊平政; | 書刊名 | 中華民國獸醫學會雜誌 |
卷期 | 25:4 1999.12[民88.12] |
頁次 | 頁262-274 |
分類號 | 437.22 |
關鍵詞 | 巨噬細胞; 抗氧化劑; 超氧化離子; 泡沫細胞; 氧化型低密度脂蛋白; Macrophages; Antioxidants; Superoxide anions; Foam cells; Oxidized LDL; |
語文 | 英文(English) |
英文摘要 | We have established an in vitro macrophage/foam cell model to evaluate intracellular oxidation of metabolized lipids. Oxidation of low density lipoprotein (LDL) is a major cause of early atherogenesis. Massive accumulation of oxidized LDL in macrophages generates foam cells, a hallmark for early atherosclerotic lesion. Since application of antioxidants to hypercholesterolemic animals in doses sufficient to protect LDL from oxidation does not generally retard atherogenesis, cellular processes associated with cytokines might play a central role during atherogenesis. We hypothesized that intracellular oxidation of metabolized lipid might correlate to these cellular processes. In the current study, we showed that superoxide anions were produced in foam cells loaded with acetylated LDL. Overexpression of interleukin-1 beta was also observed. We concluded that intracellular oxidation in foam cells is closely associated with the generation of superoxide anions and overexpression of interleukin-1 beta. |
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