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題 名 | Modulation of Nicardipine HCl Release from Pellets Using the Natural Polyaminosaccharide Chitosan=使用天然聚氨醣Chitosan調整Nicardipine HCl自圓粒的釋離 |
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作 者 | 林恆弘; 游慧美; 許立人; | 書刊名 | 嘉南學報 |
卷 期 | 25 1999.11[民88.11] |
頁 次 | 頁114-122 |
分類號 | 418.632 |
關鍵詞 | 圓粒; 幾丁質; 溶離; 熱卡式分析; Nicardipine HCl; Pellet; Chitosan; Dissolution; DSC; |
語 文 | 英文(English) |
中文摘要 | 在研發經口投與之藥物控釋劑型的前提下,我們嘗試使用Avcel與乳糖二者混合 物經由擠出搓圓技術來製備圓粒,並選擇nicardipneHC1為模式藥物:添加濃度為重量百分 比5%。本研究在探討影響圓粒圓度與其藥物釋離特性之因素,以獲致有關的基本資訊。結果 指出,此製備技術所產製的圓粒其粒徑介於500至3000m之間,圓粒的成粒與藥物溶離可藉 由添加chitosan在黏合劑中而獲得極大的改善,而適宜的chitosan添加濃度是重量百分比 0.2%。至於圓粒中各組成分之間的交互作用,則採用熱分析來加以檢測。 |
英文摘要 | In the development of controlled release dosage forms for oral administration, we attempt to prepare pellets using binary mixtures of Avicel and lactose as bulk materials by extrusion- spheronization method. Nicardipine HC1 was chosen as a model drug at a concentration of 5 % (w/w). The present study was performed to obtain basic information for factors effecting granulation and drug release characteristics of pellets. The results indicated that the technique is suitable to obtain pellet of particle sizes ranging from 500 to 3000μm. The granulatablility of pellets and the drug dissolution was optimal chitosan concentration was around 0.2 % (w/w). Furthermore, The interaction among the components of pellet was examined by DSC. |
本系統中英文摘要資訊取自各篇刊載內容。