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題 名 | Upregulation of IL-5 Receptor Expression on Bone Marrow-derived CD34狇Cells from Patients with Asthma=氣喘病患向上調節骨髓中的CD34陽性細胞之第五介白質接受器的表現 |
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作 者 | 周俊良; 王圳華; 郭漢彬; | 書刊名 | 長庚醫學 |
卷 期 | 22:3 1999.09[民88.09] |
頁 次 | 頁416-422 |
分類號 | 415.425 |
關鍵詞 | 第五介白質接受器阿爾發次單位; 嗜伊紅性白血球; 骨髓先驅細胞; 第五介白質; 氣喘; Interleukin-5 receptor α- subunit; Eosinophil; Bone marrow-derived progenitor cells; Interleukin-5; Asthma; |
語 文 | 英文(English) |
中文摘要 | 背景:第五介白質(IL-5)是一種強效的嗜伊紅性白血球生成因子,一般認為它和氣 喘病患的慢性發炎細胞累積有關。我們研究骨髓中CD34陽性光驅細胞中IL-5接受器阿爾 發次單位(IL-5Rα)的表現,以證實氣喘病患的先驅細胞,較易受到IL-5的作用。 方法:我們取6位氣喘病患及3位非氣喘志願者的骨髓血液,分離出非黏附性、非T 淋巴球細胞(NANT cells),以免疫螢光的方式染色,並用流式細胞儀分析CD34及IL-5Rα。 並將部分細胞培養14天後,觀察其群落生長的情形。 結果:本研究中氣喘病患骨髓中的CD34陽性細胞,表現IL-5Rα的細胞比例增加(12.9 ±3.3%,n=6;志願者:1.8±0.6%,n=3,p<0.01)。同時細胞培養的群落中,有明顯朝向嗜伊 紅性白血球分化的趨勢。 結論:本研究的結果顯示,氣喘病患骨髓中的先驅細胞有增加IL-5Rα表現的現象。這 個結果支持氣喘病患的骨髓細胞趨向嗜伊紅性白血球分化的論點。 |
英文摘要 | Background: Familial hypercholesterolemia is associated with a very high risk of premature coronary heart disease. In order to identify cases of familial hypercholesterolemia in Taiwan, we screened the hyperlipidemic patients in our metabolic clinics. Methods: Hyperlipidemic patients were screened in the metabolic outpatient department and the cases which fulfilled the clinical criteria of definitive or possible familial hypercholesterolemia were further analyzed. Their clinical characteristics, including age, gender, physical findings, past history of coronary heart disease or cerebrovascular accident (CVA), family history, and lipid profiles before and after medical treatment, were reviewed. Results: Eight women and 3 men fulfilled the diagnostic criteria. The mean age at diagnosis was 51.1±11.9 years old. Tendon xanthomas were found in 5 patients with definitive familial hypercholesterolemia. Coronary heart disease was confirmed in one patient and old CVA was noted in another 2 patients. The mean total cholesterol level was 390.3±88.9 mg/dl and the mean low density lipoprotein-cholesterol (LDL-cholses-terol) level was 309.6±89.9 mg/dl before treatment. After a mean treatment duration of 45.2 months, the mean total cholesterol level and LDL- cholesterol level were 326.8±87.8 mg/dl and 249.1±91.1 mg/dl, respectively. Conclusion: Clinically diagnosed familial hypercholesterolemia indeed exists in Taiwan. As compared to other reports, the mean age at diagnosis in our series was older and the majority of patients were women. Most patients were not vigorously treated and the family members were not throughly screened. Adequate treatment of patients with familial hypercholesterolemia in clinical practice and screening their family members are crucial in preventing new or recurrent coronary heart disease. |
本系統中英文摘要資訊取自各篇刊載內容。