查詢結果分析
相關文獻
- Effects of Glycyrrhizae and Glycyrrhizic Acid on Cellular Immunocompetence in Low-Dose γ-Ray Irradiated Mice
- 甘草酸對芍藥苷藥物動力學之影響
- Comparison of Pharmacokinetics between Glycyrrhizin and Glycyrrhetic Acid in Rabbits
- Simultaneous Analysis of Six Components in "Chai-Hu-Kuei-Chih-Tang" by High Performance Liquid Chromatography
- Effects of Licorice and Its Active Principles on Carrageenan-Induced Edema of the Rat Hind-Paw
- 中西藥交互作用體內--體外試驗模型之建立及相關性探討(2-1)
- Pharmacokinetic Difference between Licorice and Honey-processed Licorice in Rabbits
- Simultaneous Analysis of Nine Components in "Byi-Liang-Tang" Preparation by High Performance Liquid Chromatography
- 中西藥交互作用體內-體外試驗模型之建立及相關性探討(2-2)
- Simultaneous Analysis of Seven Components in Hsiao-Ching-Lung-Tang Preparation by High Performance Liquid Chromatography
頁籤選單縮合
題 名 | Effects of Glycyrrhizae and Glycyrrhizic Acid on Cellular Immunocompetence in Low-Dose γ-Ray Irradiated Mice=甘草與甘草酸對於照過低劑量γ-射線鼷鼠細胞免疫力的影響 |
---|---|
作 者 | 林宜信; 郝道猛; 游智勝; 黃惠棻; 陳洸艟; 邱義陽; | 書刊名 | 長庚醫學 |
卷 期 | 22:3 1999.09[民88.09] |
頁 次 | 頁370-377 |
分類號 | 414.82 |
關鍵詞 | 甘草; 甘草酸; 低劑量γ-射線; 細胞免疫力; Glycyrrhizae; Glycyrrhetinic acid; Low-dose γirradiation; Cellular immunocompetence; |
語 文 | 英文(English) |
中文摘要 | 背景:對於人類及動物遭受游離幅射傷害的防護與修復實很重要。本研究旨在探 討甘草及甘草酸對於照射低劑量(1 Gy) γ-射線鼷鼠細胞免疫力的影響。 方法:選取ICR種系(由美國癌症研究所育種的Crl:CD-1-ICR(BR)種系),年約6-8週的 雄性鼷鼠作為實驗動物,分成4組。A組為正常對照組。B組為實驗對照組,僅接受1Gy 的γ-射線的全身照射。C組及D組為實驗組,在幅射後分別每天1次共計10次,接受500 mg/kg體重的甘草(口服)及5 mg/kg體重的甘草酸(腹膜注射)的處理。實驗動物分6批犧牲, 分析每組動物的白血球分類計數及細胞免疫力。 結果:1Gy的γ-射線對鼷鼠的白血球及其分類計數,以及細胞免疫力均有明顯的抑制 作用。甘草及甘草酸能幫助因照過1Gy的γ輻射而降低的鼷鼠白血球的分類計數及其細胞 免疫力提早恢復。 結論:甘草及甘草酸能幫助鼷鼠提早恢復受低劑量幅射而降低的白血球分類計數,以及 細胞免疫力。 |
英文摘要 | Background: For both animals and human beings, it is important to prevent damage from ionizing radiation and to restore immunocompetence following irradiation. The present study was conducted to investigate the effects of glycyrrhizae (GL) and glycyrrhetinic acid (GA) on cellular immunocompetence in low dose γ-ray-irradiated mice. Methods: Six-to 8-week-old ICR strain' Crl:CD-1-ICR(BR) strain male mice, bred in the Institute of Cancer Research, U.S.A., were chosen and divided into four groups. Group A was the normal control. Group B, the experimental control, received 1Gy of whole bodyγ-ray-irradiation. Groups C and D, the experimental groups, were treated with 500mg/kg of GL(orally) and 5 mg/kg body weight of GA(i.p.), respectively, once a day, 5 days a week for 2 weeks afterγ-irradiation. The tested mice were killed, at 6 different inteals to measure their leukocyte and differential counts. Cellular immunocompetence was measured by the H-thymidine uptake in each group. Results: One gray ofγ-ray-irradiation had evident inhibition on the leukocyte and differential counts and the cellular immunity of mice. GL and GA could help to restore the decreased leukocyte counts and the cellular immunocompetence in low doseγ-irra-diated mice. Conclusion: GL and GA could help to restore decreased leukocyte counts and the cellular immunocompetence in low-doseγ-ray-irradiated mice. |
本系統中英文摘要資訊取自各篇刊載內容。