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題名 | Treatment Results of Polymorphic Reticulosis at Veterans General Hospital-Taipei=臺北榮民總醫院多形性網細胞增多症之治療成果 |
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作者 | 夏錫生; 梁棉榮; 曾玉華; 許志宏; 李永賢; 季匡華; 陳光耀; 趙靜宜; 顏上惠; | 書刊名 | 放射治療與腫瘤學 |
卷期 | 6:1 1999.03[民88.03] |
頁次 | 頁25-32 |
分類號 | 415.6、415.6 |
關鍵詞 | 多形性網細胞增多症; 放射治療; 惡性淋巴腫瘤; Polymorphic reticulosis; Radiotherapy; Malignant lymphoma; |
語文 | 英文(English) |
中文摘要 | 目的:回顧過去十五年(1982-1997)在臺北榮民總醫院多形性網細胞增多症(現 已改稱為中央血管增生型 T- 細胞淋巴症)之治療成果。材料與方法:自 1982 年 12 月至 1997 年 12 月共有 40 例罹患多形性網細胞增多症之病患在臺北榮民總醫院就診, 其 35 名為男性,5 名為女性,其年齡介於 14 至 78 歲之間,追蹤期間為 1 至 172 個月。經整 理每一病患之病歷, 以追溯其病史,臨床及生化血液檢驗、X 光檢查及治療方式。 其中 5 名病患只接受化學治療, 19 名病患接受放射治療,另 16 名病患接受合併放射、化學或外 科治療。 結果:全體 40 名病患無疾病 5 年存活率為 35 %,單接受放射治療之病患,其 5 年無疾病存活率為 57 %,接受放射治療合併化學治療或外科治療者為 19 %,若扣除放 射治療合併化學治療者則僅剩 8 %。 患灶數目( =1 ),身體狀況( K scale>70 ),治 療方式無手術治療為有統計意義之較佳預後因子。 40 例病患有 23 例因病死亡,其中有 5 例遠端轉移,4 例局部復發,其他 14 例有包括敗血症、肺炎及出血有關之病症而死亡,因 病歷記載未詳盡,無法判斷上述 14 例死因是否與原發病灶有關。 15 例有接受過化療者僅 有 2 例復發,25 例無接受化療者有 7 例復發。 結論:多形性網細胞增多症,局部放射治 療之結果良好,化學治療對防止復發有利。病灶數目只有一處,身體狀態 K scale 大於 70 分,未曾接受手術者為較佳的預後因子。 |
英文摘要 | Purpose:Retrospectively review the treatment results of polymorphic retculosis ( now called angiocentric T-cell lymphoma ) patients at Veaterans eneral Hospital-Taipei over the past fifteen years ( 1982-1997 ).Materials and Methods: From December 1982 to December 1997, there were 40 patients diagnosed of polymorphic reticulosis at Veterans General Hospital-Taipei. There were 35 male patients and 5 female patients. The age of the patients ranged from 14 to 78 years old. The follow-up period ranged from 1 to 172 months. Medical histories, laboratory and X-ray examinations and modalities of treatment from medical records of each patient were reviewed. Five patients received chemotherapy alone, 19 patients received radiotherapy alone and 16 patients received radiotherapy combined with chemotherapy or surgery. Results:The 5-year disease-free survival rate of all patients was 35 %.The 5-year disease-free survival rate for patients receiving radiotherapy alone was 57 %. It was 19 % for patients treated with radiotherapy plus surgery, chemotherapy or both; and 8 % only for patients received surgery combined with other treatments. Number of involved sites ( =1 ), Karnofsky scale ( >70 ), non-surgery treatment are positive statistical prognostic factors. There were 23 patients died and 9 of them have evidence of disease progression ( 5 cases of distant metastasis and 4 cases of locoregional recurrence ). There were 2 patients relapsed in 15 patients who received chemotherapy, and there were 7 patients relapsed in 25 patients who without chemotherapy. Conclusion: Polymorphic reticulosis had excellent local control rate by radiotherapy. Chemotherapy may be benefit for prevention of distant metastasis and local recurrence. Number of involved site ( s ), good Karnofsky scale, and non-surgical treatment are associated better prognosis. |
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