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題名 | 茵陳蒿湯之抗氧化作用的研究=The Study on the Antioxidative Effect of Inchenhau-Tang |
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作者 | 陳明豐; | 書刊名 | 中醫藥年報 |
卷期 | 17:2 1999.05[民88.05] |
頁次 | 頁513-525 |
分類號 | 414.5 |
關鍵詞 | 茵陳蒿湯; 抗氧化作用; 急性肝炎; 超氧陰離子; 過氧化氫; 過氧化脂質; Inchenhau-tang; Antioxidative effect; Acute hepatitis; Superoxide anion; Hydrogen peroxide; Lipid peroxide; |
語文 | 中文(Chinese) |
中文摘要 | 我們在過去的研究中發現,十二種常用保肝中藥方劑中以茵陳蒿湯的抗氧化活性 最為明顯。由於茵陳嵩湯經常被使用於治療急性肝炎,因此,本研究進一步觀察茵陳嵩湯對 急性肝炎患者之全血超氧陰離子 (O2□ )及過氧化氫 (H�烙��)之清除作用,並進一步探討 茵陳嵩湯的組成三種中藥大黃、茵陳嵩及桅子之抗氧化作用。結果發現,茵陳嵩湯水萃取物 可以顯著地清除急性肝炎患者全血中的超氧陰離子及過氧化氫,但以清除超氧陰離子的作用 較明顯。另一方面,茵陳蒿湯的三種組成生藥大黃、茵陳嵩、桅子之水萃取物都具有清除由 黃嗓吟 / 黃嗓吟氧化脢產生之超氧陰離子的作用, 並且能抑制氯化亞鐵誘發大白鼠肝細胞 脂質過氧化,三種中藥的抗氧化活性中以大黃最顯著。由以上結果顯示,茵陳嵩湯能有效地 清除急性肝炎患者全血中之氧自由基,而三種組成中藥中又以大黃為最強的抗氧化劑。 |
英文摘要 | In our previous study, we found that lnchenhau-Tang(ICHT) is a most strong anti-oxidant among twelve herb drug prescriptions which are popularly used in treatment of liver disease. ICHT is mostly used in treatment of acute hepatitis with jaundice. Therefore, in this study we further investigated the scavenging effect of ICHT on the oxygen radicals including superoxide anion(02 □) and hydrogen peroxide (H�烙��) in the whole blood of patients with acute hepatitis. On the other hand, we also investigated the anti-oxidative effect of Artemisiae Capillaris Herba(ACH), Gardeniae Fructus(GF), and Rhei Rhizoma(RR) which are composed of ICHT. The results show that, the watery extract of ICHT significantly scavenged both superoxide anion and hydrogen peroxide in the whole blood of patients with acute hepatitis. The scavenging effect of ICHT on superoxide anion was greater than that on hydrogen peroxide. On the other hand, all of watery extracts of three composed herb drugs significantly scavenged superoxide anion produced by xanthine/xanthine oxidase, and markedly inhibited the production of lipid peroxide from rat liver cells induced by FeCl��. Among them, RR had most strong antioxidative effect. The above results revealed that watery extract of ICHT can scavenge oxygen radicals in the whole blood of patients with acute hepatitis. Among three composed herb drugs of ICHT, RR is a most important antioxidant. |
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