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題 名 | Clinical Experience of Ketogenic Diet on Children with Refractory Epilepsy=生峒飲食用於兒童頑固性癲癇之臨床經驗 |
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作 者 | 麥淑珍; 遲景上; 萬居仁; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷 期 | 40:2 民88.03-04 |
頁 次 | 頁97-100+138 |
分類號 | 417.5845 |
關鍵詞 | 生峒飲食; 頑固性癲癇; Ketogenic diet; Refractory epilepsy; |
語 文 | 英文(English) |
中文摘要 | 自1997年9月,共13位頑固性癲癇兒童接受生酮飲食(中鏈脂肪酸油飲食)作輔助治療。 臨床的癲癇型態包括全身性強直一痙縮發作,Lennox-Gastaut症候群,肌抽躍發作,全身性強直+ 失張力發作,複雜性局部發作。臨床觀察的重點在生酮飲食的療效及副作用。結果發現在生酮飲食 一個月後,53.8%的病人有>75%的癲癇發作減少;76.6%的病人有>50%的癲癇發作減少。6位病 人有不等程度的認知及學業上的進步。最常見的副作用包括體重減輕(n=6)及腹瀉(n=5),其他尚包括 脾氣變差(n=1),腹痛(n=2),嘔心(n=2),異常體味(n=1),泌尿道結石(n=1)等。在停用生酮飲食後, 有61.5%的病人仍然有>50%的癲癇發作減少。我們認為生酮飲食在頑固性癲癇的兒童是值得一試 的。 |
英文摘要 | Thirteen children with refractory epilepsy received a ketogenic diet (medium chain triglyceride oil diet) as an alternative therapy since September 1997. Their seizure patterns included (1) generalized ronic+clonic seizures, (2) myoclonic seizures, (3) generalized tonic+atonic seizures, (4) complex partial seizues, (5) generalized clonic+atonic+myoclonic seizures, (6) head nodding+myoclonic+gelastic seizures, and (7) generalized tonic-clonic+myoclonic+atonic seizures. Major concerns emphasized on the efficacy and side effects of the dier. Clinical observation one month after the diet revealed that 53.8% of the patients had a > 75% reduction in seizure frequency and 76.9% of the patients had a > 50% reduction in seizure frequency. Six patients had some degress of improvement in cognitive function and/ or school performances. The most common side effects were body weight loss (n=6) and diarrhea (n=5). Others included bad temper (n=1), abdominal cramps (n=2), nausea (n=2), bad body smell (n=1), and renal stones (n=1). Even after sidcontinuation of the diet, 61.5% of patients still had a > 50% reduction in seizure frequency. We concluded that the ketogenic diet deserves a trial in children with refractory epilepsy. |
本系統中英文摘要資訊取自各篇刊載內容。