查詢結果分析
相關文獻
- Effect of Topiramate on Intractable Seizures in Taiwanese Children
- Systemic Penicillium Marneffei Infection in a Child with Common Variable Immunodeficiency
- Klebsiella Pneumoniae Liver Abscess in Childhood--A Case Report
- Congenital Duodenal Membrane: A Ten-year Review
- Clinical Experience of Ketogenic Diet on Children with Refractory Epilepsy
- The Ilizarov Technique for Treatment of Sequelae of Childhood-Acquired Bone and Joint Infection
- 游離輻射暴露對孩童成長影響之探討
- 孩童及青少年血脂異常的治療
- Elder Abuse in the United States
- Conservative Treatment of Intra-Abdominal Abscess in Children
頁籤選單縮合
題名 | Effect of Topiramate on Intractable Seizures in Taiwanese Children=妥泰用於臺灣頑固性癲癇孩童之功效評估 |
---|---|
作者姓名(中文) | 李松澤; 沈淵瑤; 邱南昌; 何啟生; | 書刊名 | Acta Neurologica Taiwanica |
卷期 | 13:2 2004.06[民93.06] |
頁次 | 頁59-63 |
分類號 | 418.21 |
關鍵詞 | 妥泰; 頑固性癲癇; 孩童; Topiramate; Intractable epilepsy; Epileptic therapy; Children; |
語文 | 英文(English) |
英文摘要 | We performed a prospective study to evaluate the effect of topiramate as an adjunctive therapy in Taiwanese children with intractable partial epilepsy and generalized epilepsy. Thirty children aged from 2 to16 years (8.5±3.8 years) were enrolled in this study. Eighteen children (60.0%) had partial epilepsy, and 12 children (40.0%) had generalized epilepsy. These children were experiencing more than one seizure per month even under a stable antiepileptic regimen treatment. Topiramate was begun at 1 mg/kg‧day, and the dosage was raised by 1 mg/kg‧day each week. Titration continued for 4 weeks or more. The maximal dosage was 10 mg/kg•day. In children with partial epilepsy, six children (33.3%) achieved≥50% frequency reduction, while eight children (44.4%) achieved a seizure-free state. In children with generalized epilepsy, including infantile spasms, four children (33.3%) achieved≥50% frequency reduction, while five children (41.7%) achieved a seizure-free state. The most common adverse effect was poor appetite (10.0%). No idiosyncratic reactions to topiramate were found. Only one patient discontinued topiramate because of central hyperventilation. Topiramate can be used as an adjunctive antiepileptic drug for intractable epileptic children in Taiwan. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。