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題 名 | The Blocking Effects of Nalmefene--A New, Potent, and Long-Lasting Opiate Antagonist: Against Myocardial Ischemia-Induced Arrhythmias in Rats=Nalmefene在心肌缺血時之作用 |
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作 者 | 李應紹; | 書刊名 | Acta Cardiologica Sinica |
卷 期 | 14:4 民87.10-12 |
頁 次 | 頁177-182 |
分類號 | 418.22 |
關鍵詞 | 鴉片對抗劑; 心肌缺血; 內出性鴉片樣胜; Opiate antagonist; Nalmefene; Myocardial ischemia; Endogenous opioid peptides; |
語 文 | 英文(English) |
中文摘要 | 背景:已有報導,在心肌缺血時,心臟鴉片受體會被激活而產生心律不整。而鴉 片對抗劑 Naloxone 則能抑制冠狀動脈結紮時產生之心律異常。本研究在進一步探討另一種 強而長效的鴉片對抗劑 Nalmefene,在心肌缺血時的作用。 方法:大白鼠經麻醉後進行人工呼吸。左邊開胸後結紮左冠狀動脈;比照組在冠狀動脈結紮 後均產生心律不整,低心跳及低血壓。 而 Nalmefene 則能抑制此等心肌缺血時產生之異常 。 結論:研究結果顯示心肌缺血會導致內生性鴉片樣胜之釋出,從而引發心律不整,低心跳及 低血壓。Nalmefene 具抑制此等心肌缺血時產生之併產症。Nalmefene 可能對缺血性心臟病 及心律不整具療效。 |
英文摘要 | Background. It has been shown that cardiac opioid receptors are activated during arrhythmias induced by myocardial ischemia, supporting the hypothesis that endogenous opioid peptides (EOPs) are involved in cardiac arrhythmogenesis and in myocardial ischemia. The opiate antagonist naloxone has been found to inhibit cardiac arrhythmias resulting from coronary artery occlusion in both in vitro and in vivo preparations. It is therefore of interest to further investigate whether another potent, long-lasting opiate antagonist, nalmefene, also blocks the cardiac effects of myocardial ischemia. Methods and Results. Spraque-Dawley rats were anesthetized and artificially ventilated. Left thoracotomy was performed and the left coronary artery was ligated. Following coronary artery occlusion, all rats in the control group developed ischemia-induced arrhythmias, bradycardia and hypotension, which were significantly inhibited by high dose pre-treatment with nalmefene. Conclusions. The results indicate that EOPs may be released when myocardial ischemia occurs, thus causing arrhythmias, bradycardia and hypotension. Nalmefene, by virtue of its antagonistic action, attenuates these fatal complications secondary to myocardial ischemia. This suggests that EOPs play an important role in ischemic heart disease and that nalmefene may have therapeutic value. |
本系統中英文摘要資訊取自各篇刊載內容。