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題名 | Infrared Absorption Study of Schiff Bases of Aminohydroxyguanidine=氨基羥基胍(Aminohydroxyguanidine)西佛鹼(Schiff Bases)之紅外光譜吸收研究 |
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作者 | 裴黃花; 連榮吉; 任士君; | 書刊名 | 藥物食品分析 |
卷期 | 6:4 1998.12[民87.12] |
頁次 | 頁679-690 |
分類號 | 418.4 |
關鍵詞 | 紅外光譜; 氨基羥基胍; 羥基执; 西佛鹼; Infrared spectroscopy; Aminohydroxyguanidines; Hydroxyurea; Schiff bases; |
語文 | 英文(English) |
英文摘要 | Schiff bases of aminohydroxyguanidine were designed to contain the essential pharmacophore of hydroxyguanidine and have structural similarity to hydroxyurea, thiosemicarbazone and N-carbamyloxyurea. Most of these compounds have been shown to have antitumor and/ or antiviral activities more potent than hydroxyurea and hydroxyguanidine. Their mode of action is inhibition of ribonucleotide reductase which is the key enzyme in de novo DNA synthesis. Their infrared spectra (IR) are determined and discussed in this paper. Possible applications of the IR data in pharmaceutical analysis are presented. |
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