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題 名 | Effect of Sensory Neuropeptides on Mucus Secretion from Cultured Goblet Cells=感覺神經胜類對培養的杯狀細胞黏液分泌的作用 |
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作 者 | 陳孝曦; 郭漢彬; | 書刊名 | 長庚醫學 |
卷 期 | 21:3 1998.09[民87.09] |
頁 次 | 頁283-290 |
分類號 | 415.31 |
關鍵詞 | 黏液分泌; 感覺神經胜類; 辣椒素; 杯狀細胞; 快動素; Mucus secretion; Sensory neuropeptides; Capsaicin; Goblet cell; Tachykinin; |
語 文 | 英文(English) |
中文摘要 | 背景:氣道杯狀細胞黏液分泌受到辣椒素激發性的感覺神經所控制。給予辣椒素 或逆向性神經傳導可刺激杯狀細胞黏液分泌,並且促使血漿滲透液增加和氣道平滑肌收縮。 這是經由神經末梢的感覺神經胜類來作用的。本研究乃探討辣椒素和感覺神經胜類,是否直 接作用在氣道杯狀細胞本身,或者是藉由其化的反應來作用。 方法:我們藉由在顯微鏡下,直接觀察培養的天竺鼠氣管杯狀細胞黏液分泌率以及放射性同 位素硫35標識的黏液樣醣蛋白(mucin-Lke glycoprotein)定量分析的方法,檢測如:物質 P(Substance P)、神經動素 A(Neurokinin A)、神經動素 B(Neurokinin B)和辣椒素對的影 響。 結果:培養的杯狀細胞,自發性的以平均每分鐘 3個的速率分泌出細胞內的顆粒物質。物質 P和神經動素 A增加黏液分泌的能力與劑量有關。在10�騎的濃度下各達到最高的黏液分泌 增加的反應,分別為52%和37%。用放射性同位素硫35標識的黏液樣醣蛋白定量分析的方法 ,物質P在10�騎的濃度下,比對照組刺激黏液分泌的能力增加了109.2%。然而神經動素B 和辣椒素對杯狀細胞黏液分泌的能力皆無影響。Thiorphan(一種enkephalinase的抑制劑 )在10�騎濃度下,對物質 P刺激放射性同位素硫35標識黏液分泌的能力並無影響。 結論:因為物質 P具有最大的刺激黏液分泌的能力,所以我們認為物質 P和神經動素 A藉 由快動素接受器的NK-1亞型,直接刺激杯狀細胞的黏液分泌。辣椒素對於培養的杯狀細胞 並無直接刺激黏液分泌的作用。 |
英文摘要 | Background: Airway goblet cell secretion is under the control of capsaicin-sensitive sensory nerves. Administration of capsaicin or antidromic stimulation of nerves can stimulate goblet cell secretion and also induce plasma exudation and smooth muscle contraction via a release of neuropeptides from sensory nerve endings in the airway. This study was designed to explore whether the effect of capsaicin or neuropeptides on goblet cell secretion is direct or secondary to other airway responses. Materials and Methods: We examined the effects of sensory neuropeptides including substance P (SP), neurokinin A (NKA) and neurokinin B (NKB), as well as capsaicin on cultured guinea pigtracheal goblet cells by measuring the rate of mucus discharge visually under a microscope and the release of SO�猛adiolabeled mucin-like glycoconjugates. Results: Goblet cells in culture spontaneously secreted intracellular granules at a mean rate of about 3 times/min. SP and NKA increased secretion in a dose-dependent manner. SP was more potent than NKA with maximum responses of 52% and 37% at 10�騎, respectively. Quantitative measurements of SO�猛adiolabeled mucin-like glycoprotein (MLGP) secreted by goblet cells also revealed an increase (109.2%) in mucin secretion caused by SP (10�騎) compared with the Vehicle control. Neither capsaicin nor NKB caused any significant change in the goblet cell secretory rate. The effects of SP on the secretory rate or release of radiolabeled mucin were not potentiated by an enkephalinase inhibitor, thiorphan (10�騎). Conclusion: Sensory neuropeptides SP and NKA directly stimulate goblet cell secretion, probably through the tachykinin receptor of the NK-1 subtype as suggested by a greater potency of SP. There was no direct effect of capsaicin on goblet cell secretion. |
本系統中英文摘要資訊取自各篇刊載內容。