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| 題 名 | Comparative Study of the Effects of Capsaicin on the Contractility of Normal and Spinal Cord Injured Human Bladders=紅辣椒素對於正常及脊髓損傷人類膀胱收縮力影響之比較研究 |
|---|---|
| 作 者 | 郭漢崇; | 書刊名 | Proceedings of the National Science Council : Part B, Life Science |
| 卷 期 | 21:1 1997.01[民86.01] |
| 頁 次 | 頁13-19 |
| 分類號 | 361.44 |
| 關鍵詞 | 紅辣椒素; 人類膀胱收縮力; Capsaicin; Micturition; Human bladder; |
| 語 文 | 英文(English) |
| 英文摘要 | 為了探討紅辣椒素對於正常及脊髓損傷人類之膀胱收縮力之影響,作者利用離體 肌肉條進行肌肉收縮研究。本研究共取用十位非脊髓損傷膀胱之正常部份,以及八位脊髓損 傷病人的膀胱做為比較研究。 在手術中取下一塊逼尿肌,並分成八條肌肉條。 其中四條以 1~1000 μ M 紅辣椒素處理, 在處理前後則以電場刺激及 bethanechol 做收縮力之測定。 另外四條事先以 40 nmole 之 [D-Arg ��, D-Trp ��, �m,Leu �� ]-substance P (spantide) 浸泡 30 分鐘,再重覆以上之實驗。 結果顯示紅辣椒素對正常及脊髓損傷之逼 尿肌具有濃度相關之收縮反應,但在不同濃度的紅辣椒處理過十分鐘後,低濃度紅辣椒素會 部刀抑制逼尿肌之收縮力, 而高濃度之紅辣椒素 (1000 μ M) 則幾乎完全阻斷逼尿肌之收 縮力。紅辣椒素引發的肌肉收縮在正常膀胱較強,但其對肌肉收縮力所造成之抑制收縮程度 則在正常及脊髓損傷無顯著的差異。在加入 spantide 後,肌肉對紅辣椒素之收縮反應,以 及隨後產生的抑制收縮作用,並無明顯的差異,顯示紅辣椒素對逼尿肌的收縮作用主要不是 經由 NK 受器,而是直接作用於肌肉細胞。而這些肌肉條在全部實驗後再度加入紅辣椒素, 並無法引發原有之收縮反應,甚至在洗完紅辣椒素之後亦不能恢復原有之肌肉收縮力。這些 結果顯示在高濃度紅辣椒素直接施於逼尿肌時,會產生直接的細胞毒性或神經慣性,使之收 縮力降低或消失。近年來臨床上廣泛使用膀胱內高濃度紅辣椒素,灌注於脊髓損傷病人,以 治療逼尿肌反射亢進。此種對於肌肉細胞之毒性應特別注意,以免在長期治療後造成無法恢 復之結果。 ntide, the initial contractile effect and the final depressant effect of capsaicin remained the same, indicating that the contractile effects of capsaicin were not mainly through NK receptors but directly on muscle cells. Consecutive application of capsaicin to the same strip could not reproduce the contractile response. After washing free of capsaicin, the detrusor contractility under electrical stimulation and bethanechol was not reversible. A direct neurotoxic or cytotoxic effect could be found after high concentration capsaicin administration. In treating patients suffering from detrusor hyperreflexia using intravesical capsaicin instillation, this effect should be considered to prevent irreversible damage to the urinary bladder. |
本系統中英文摘要資訊取自各篇刊載內容。