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- Treatment of Hypersensitive Bladder and Interstitial Cystitis by Intravesical Instillation of Capsaicin
- Symptomatic Characteristics and Impact on Quality of Life in Patients with Interstitial Cystitis
- 令內外科醫生都困惱的疾病--間質性膀胱炎
- 間質性膀胱炎的診斷及治療
- Urodynamic Results of Intravesical Heparin Therapy for Women with Frequency Urgency Syndrome and Interstitial Cystitis
- Comparative Study of the Effects of Capsaicin on the Contractility of Normal and Spinal Cord Injured Human Bladders
- Reversibility of the Inhibitory Effect of Intravesical Capsaicin on the Micturition Reflex in Rats
- 間質性膀胱炎[Interstitial Cystitis, IC]
- 惱人的間質性膀胱炎
- Capsaicin Inhibits Detrusor Contractility but not the Micturition Reflex in Capsaicin-Desensitized Rats
頁籤選單縮合
題名 | Treatment of Hypersensitive Bladder and Interstitial Cystitis by Intravesical Instillation of Capsaicin=膀胱內灌注紅辣椒素治療超敏感性膀胱及間質性膀胱炎 |
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作者姓名(中文) | 郭漢崇; | 書刊名 | 慈濟醫學 |
卷期 | 6:4 1994.12[民83.12] |
頁次 | 頁239-244 |
分類號 | 415.835 |
關鍵詞 | 紅辣椒素; 超敏感性膀胱; 間質性膀胱炎; Capsaicin; Hypersensitive bladder; Interstitial cystitis; |
語文 | 英文(English) |
中文摘要 | 紅辣椒素已經證實對哺乳類動物的膀胱內之無髓鞘感覺神經纖維具有 特別的作用,可以使神經末梢大量釋放出substance P,並且使得由這些神經所傳 遞的感覺受到影響。紅辣椒素在臨床上已被使用於治療脊髓損傷所產生之逼尿肌 反射亢進,以及超敏感性膀胱的疼痛及頻尿症狀。為了更進一步厘清紅辣椒素在 膀胱感覺性障礙疾病的治療效果,作者選擇10位超敏感性膀胱(HSB)患者以及10 位具間質性膀胱炎(IC)的患者進行此一前行性研究。 所有的病人均經過臨床明確的診斷,但對於傳統抗乙醯膽胺治療無效,而且均有 頻尿、急尿、夜尿、尿量少及恥骨上疼痛等膀胱刺激症狀。我們先以含有10μM 紅辣椒素之生理鹽水進行膀胱壓力圖及尿流速,隨後以30毫升內含10μM紅辣椒 素之生理鹽水每週灌注膀胱一次,一共進行六週。共有8位HSB病人在灌注後3-5 天內症狀明顯改善或消除,但隨後症狀即恢復直至下一次灌注為止,繼續灌注亦 不會使有效期間增長。在IC病人群中只有2位覺得症狀略有改善,而且有效期間 僅在灌注後2-3天而已,其餘8人完全無效。 使用紅辣椒素灌注膀胱後並無任何副作用或尿路感染發生。但是以10μM濃度灌 注膀胱卻因其有效期間太短以及膀胱的刺激症狀,使得用於治療HSB及IC病人的 臨床用途受到影響。如何改良灌注的濃度、頻率、方法使得臨床效果更好應是繼 續研究的目標。(慈濟醫學1994;6:239-244) |
英文摘要 | Capsaicin has been proven to exert a selective action on certain uumyelinated sensory fiberin the urinary bladder. This drug lias been used in treatment of detrusor hyperreflexia in spinalcord injury and bladder pain in hypersensitive patients with good results. In order to further clarifythe effect of capsaicin on bladder hypersensitivity, 10 patients with hypersensitive bladder (HSB)and 10 with interstitial cystitis (IC) entered this prospective study. The patients were' refractoryto conventional anticholinergic therapy and were bothered with symptoms of frequency, nocturia,small urine amount and/or suprapubic pain. Cystometry was performed with the medium containing 10 μM capsaicin in every patients. Then. normal saline containing 10 μM capsaicin was instilled into the bladder once per week for a total of 6 sessions. Eight HSB patients had symptomsrelieved in the first 3 to 5 days but relapsed thereafter, further treatment could not prolong theresponse duration nor desensitization achieved. In IC patients, only 2 felt symptoms relief in thefirst 2 to 3 days, the other 8 showed no response. There was no side effect nor infection relatedto capsaicin instillation. The short duration of effect limits the clinical application of capsaicinon HSB and IC. (Tw-Chi Med J 1994; 6: 239-244) |
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