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題名 | Worm Recovery and Precipitin Antibody Response in Guinea Pigs and Rats Infected with Clonorchis Sinensis=中華肝吸蟲在實驗動物之蟲體回收與抗體反應研究 |
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作者 | 蘇霩靄; 王福寅; 祁寶瑜; | 書刊名 | 微免與感染雜誌 |
卷期 | 31:4 1998.12[民87.12] |
頁次 | 頁211-216 |
分類號 | 414.86 |
關鍵詞 | 中華肝吸蟲; 蟲體回收; 抗體反應; Clonorchis sinensis; Precipitin antibodies; Guinea pig; Rat; |
語文 | 英文(English) |
英文摘要 | 天竺鼠及大白鼠分別經口感染200及100個中華肝吸蟲囊幼,二者在感染後1至8週 每週、及第 12、16、20、30 週,分別犧牲 5 隻動物,收集膽汁、血清、及蟲體。 實驗期 間蟲體回收率之總平均各為天竺鼠:18.7%、大白鼠:12.4%。 感染 20 週之 5 隻大白鼠中 僅一鼠帶一蟲而 30 週者無一帶蟲。以雙向免疫擴散法測試抗中華肝吸蟲抗體,顯示膽汁中 無可測之抗體,而血清中之抗體則在感染後 3 至 4 週出現。 至少 95% 的感染後 4 至 30 週之天竺鼠及 3 至 16 週之大白鼠為抗體陽性。 感染 12 週以上之大白鼠的抗體陽性率與 是否帶蟲呈正相關。 I. By a double diffusion test, no antibodies were detected against C. sinensis adult antigens in the bile juice. Serum antibodies were detected in at least 95% of the infected guinea pigs between 4-30 WPI and rats between 3-16 WPI. Precipitin antibodies seemed to be correlated with the presence of live worms in rats that had been infected for more than 12 weeks. |
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