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題名 | Serum Vitamin a Level in Breast Cancer Patients=乳癌患者的血清維生素A值 |
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作者 | 侯明鋒; 蔡麗玉; 黃哲人; 黃裕勝; 謝建勳; 黃宗人; 陳漢文; 王照元; Hou, Ming-feng; Tsai, Li-yi; Huang, Che-jen; Huang, Yu-sheng; Hsieh, Jan-sing; Huang, Tsung-jen; Chen, Hon-man; Wang, Jaw-yuan; |
期刊 | The Kaohsiung Journal of Medical Sciences |
出版日期 | 19981100 |
卷期 | 14:11 1998.11[民87.11] |
頁次 | 頁673-678 |
分類號 | 416.226 |
語文 | eng |
關鍵詞 | 乳癌; 維生素A; Breast cancer; Vitamin A; |
中文摘要 | 維生素A值與它的合成物有強力控制細胞的分化,且在動物實驗中可以預防上皮細胞癌。而一些研究顯示血清高濃度的維生素A可以降低癌症,但仍有爭論。 本研究是針對台灣地區乳癌病患測定,其術前血清中維生素A的變化,全部106例女性乳癌患者(年齡30至57歲),32例乳房良性疾病患者(年齡29至57歲)及40例健康女性(年齡22歲至52歲),收集其血清,利用比色分析法測定維生素A值。結果顯示,乳癌患者其維生素A平均值為 140.4±65.7 ug/dl,良性乳癌疾病則為145±44.2 ug/dl,而控制組則為144.0±30.0 ug/dl,這三者之間比較,並無統計上的差異(P > 0.05),而乳癌患者的血清維生素A變化與其年齡疾病期間,荷爾蒙接受器,腫瘤大小,停經與否均無關係(P > 0.05)。 維生素A血清濃度在乳癌患者並未明顯下降,但是在乳癌患者其肝臟轉移者則有意義的降低(P<0.05),術後補充維生素A可能只對轉移性乳癌者較有益效但仍待研究。 |
英文摘要 | Vitamin A Or its synthetic analogues are potent in controlling cell differentiation and in preventing epithelial cancer in experimental animals. Although some community-based studies have found that high serum retinol levels in prediagnostic sera were associated with reduced risk for cancer, other reports in humans have not confirmed this finding. This study is to evaluate the preoperative serum vitamin A level in breast cancer patients in Taiwan. The serum specimens were collected from 106 female cases if breast cancer (aged 30 to 70 years), 32 female cases of benign breast disease (aged 29 to 57 years), and 40 healthy females (aged 22 to 52 years). The serum vitamin A levels were measured by colorimetic analysis. The results showed the mean value of the vitamin A level was 140.4±65.7 ug/dl in the breast cancer group comparing to 145.2±44.2 ug/dl in the benign breast disease group, 144.0±30.0 ug/dl in the control group (P>0.05). The characteristics of the breast cancer group were analyzed and they revealed that serum vitamin A levels did not bear statistically significant differences in age, duration, steroid receptor, tumor size and menopausal state. (P > 0.05) In conclusion, the serum vitamin A levels were not decreased in early breast cancer patients. The serum vitamin A levels were significantly decreased in the metastatic breast cancer group, especially in liver metastatic women.(P < 0.05). Postoperative vitamin A supplement may have potential benefit to metastatic breast cancer patients. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。