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- 細胞骨架與神經退化性疾病
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題 名 | C-jun Expression in Patients With Parkinson's Disease=巴金森氏病人C-jun之表現 |
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作 者 | 劉崇祥; 李正淳; 邱百誼; 鍾楊聰; 陳秀宜; | 書刊名 | 中臺灣醫學科學雜誌 |
卷 期 | 4:2 1999.06[民88.06] |
頁 次 | 頁104-108 |
分類號 | 415.83 |
關鍵詞 | 多巴明致效劑; 神經退化; 反轉錄聚合酶連鎖反應; 轉錄因子; Dopamine agonist; Neurodegeneration; Reverse transcription-polymerase chain reaction; Transcription factor; |
語 文 | 英文(English) |
中文摘要 | 巴金森氏症是一種常見的神經退化性疾病,近期報告指出誘發性轉錄因子如c-fos及c-jun可能與某些神經退化性疾病如阿滋海默症、肌萎縮性側索硬化症、多發性硬化症有關。本研究因而探討巴金森氏症病人血中淋巴球內。C-jun之表現是否與正常人不同。病人與健康者服用多巴明致效劑pergolide之前與之後2、4、6及24小時各抽血一次,淋巴球之核糖核酸經過萃取後,進行反轉錄聚合醣連鎖反應。實驗結果顯示巴金森氏症病人淋巴球之c-jun RNA於服用pergolide 4小時後為未服藥前之140﹪,且經歷於24小時後仍有顯著升高現象;反之,正常人淋巴球之c-jun RNA則於服藥後6小時後顯著降低(為未服藥前之63﹪)。本實驗結果顯示巴金森氏症病人淋巴球之c-jun RNA之表現與正常人有顯著的差異,此結果與其他報告一致,支持c-jun過度表現與神經細胞退化有關之可能性。 |
英文摘要 | Parkinson's disease is a common neurodegenerative disease. Inducible transcription factors, such as c-fos and c-jun, have been implicated in neurodegenerative diseases, such as Aizheimer's disease, amyotrophic lateral sclerosis and multiple sclerosis. The present study investigated c-jun expression in the lymphocytes from patients with Parkinson's disease following dopamine agonist pergolide administration. Venous blood samples were drawn before and at 2, 4,6 and 24 hours following pergolide administration. Total RNAs were extracted from lymphocytes and subjected to reverse transcription-polymerase chain reaction. Our results showed that following pergolide administration, c-jun RNA in the lymphocytes from patients with Parkinson's disease was significantly activated to 140% of basal level at 4 hours following pergolide administration and still remained activated at 24 hours. In contrast, c-jun RNA in the lymphocytes from healthy individuals was not activated; instead it decreased to 63% of basal level at 6 hours. |
本系統中英文摘要資訊取自各篇刊載內容。