頁籤選單縮合
題 名 | 山葡萄粗抽取物及其活性成分之鎮痛抗炎作用研究=Studies of Anti-Inflammatory and Analgesic Effects of Ampelopsis Brevipedunculata |
---|---|
作 者 | 謝文聰; 譚思濰; 陳介甫; 蔡輝彥; | 書刊名 | 中國醫藥學院雜誌 |
卷 期 | 7:3 1998.09[民87.09] |
頁 次 | 頁81-87 |
分類號 | 418.52 |
關鍵詞 | 山葡萄; 鎮痛; 抗炎; Ampelopsis brevipedunculate; Anti-inflammatory and analgesic effects; |
語 文 | 中文(Chinese) |
中文摘要 | 山葡萄Ampelopsis Brevipedunculata(Maxim.)Trautv生長台灣各地山區闊葉林中,民間主要用於利尿、消炎、止血。據預試驗顯示,山葡萄甲醇抽出物有減少小鼠醋酸誘發扭體反應作用。本研究證實山葡萄中含β-sitosterol,lupeol,β-amyrin,vanillic acid,(+)-catechin,quecertin,gallic acid,betulin,ethyl gallate,kaempferol,and resveratrol數種成分。並就福馬林舔足法及鹿角菜膠誘發大白鼠後足蹠浮腫等抗發炎實驗,探討山葡萄粗抽取物及其活性成分之鎮痛作用機理。根據實驗結果顯示,山葡萄明顯的鎮痛抗炎作用,其作用及其所含活性成分可能來自於lupeol,betulin,quercetin及resveratrol有關,其抗炎鎮痛作用機理正探討中。 |
英文摘要 | Ampelopsis brevipedunculata (Ab), distributed in the broad-leaved forests throughout Taiwan, was fradihonally used as an anit-inflammatory, diuretic, and homeostatic agent in the folk medicine. In the preliminary experiments, we found that the methanol extract of Ab could inhibit acetic acid-induced writhing response in mice. Several compounds have been isolated from the roots of Ab and identified as β-sitosterol, β-sitosteryl-glycoside, β-amyrin, lupeol, betulin, vanillic acid, gallic acid, catechin, quercetin, kaempferol, and resveratrol. With respect to the anti-inflammatory effcets of those phenolic constituents, we found that lupeol, betulin, quercetin, and resveratrol could inhibit formalin-induced licking response in mice and inhibit the carrageenin-induced hind-paw edema test in rats. The results suggested that the anti-inflammatory and analgesic effects of Ab might be related to its steroids and phenolic compounds. The underlying mechanism of those components remains to be elucidated. |
本系統中英文摘要資訊取自各篇刊載內容。