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題名 | Urinary Endothelin-1 in Children with Acute Renal Failure of Tubular Origin=腎小管性急性腎衰竭孩童之尿中內皮素 |
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作者 | 曹永魁; 蔡文雄; 陳炯暉; | 書刊名 | 臺灣醫學會雜誌 |
卷期 | 97:6 1998.06[民87.06] |
頁次 | 頁387-391 |
分類號 | 417.5742 |
關鍵詞 | 腎小管性急性腎衰竭; 孩童; 尿; 內皮素; Endothelin-1; Acute renal failure; Children; |
語文 | 英文(English) |
英文摘要 | To understand the changes of urinary endotheline-1 (ET-1) concentrations in acute renal failure (ARF) and to investigate the origin of human urinary ET-1, we studied urinary ET-1 excretion in 70 normal children and 12 children with ARF caused by tubular dysfunction. Urinary ET-1 excretion was expressed as a ratio of urinary ET-1 to urinary creatinine (ET-1/Cr). Among healthy children, the highest urinary ET- 1/Cr values were found during infancy. In patients with ARF, there was a positive correlation between urinary ET-1/Cr values and daily total urinary ET-1 (r = 0.42, n = 26, p < 0.05). Plasma ET-1 concentrations were elevated in children with ARF during the period of peak serum creatinine concentration. During the course of ARF, the lowest urinary ET-1/Cr value occurred during the period of peak serum creatinine, whereas the plasma FT-i concentration declined after the peak. These results provide insight into the developmental changes of urinary ET-1 values in normal children, and illustrate the pattern of changes in plasma and urinary ET-1 concentrations during the course of ARF in children. The results suggest that renal production, rather than clearance from the circulation by glomerular filtration, may be the source of urinary ET-1. |
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