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題名 | Urinary N-Acetyl-Beta-Glucosaminidase in Normal Chinese Children and Children with Pyelonephritis=正常中國孩童及腎盂腎炎病童尿中之N-Acetyl-Beta-Glucosaminidase (NAG) 活性 |
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作者 | 曹永魁; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷期 | 32:1 民80.01-02 |
頁次 | 頁24-30 |
分類號 | 415.139 |
關鍵詞 | 中國; 尿; 孩童; 活性; 病童; 腎盂腎炎; |
語文 | 英文(English) |
中文摘要 | 測定不同年齡一百二十位正常中國孩童之尿中NAG發現兩歲以下之嬰幼兒有較高之NAG值,兩歲以上者則與成人無異,且NAG值男女並無差別,各年齡層之正常值分別為新生兒31.99±15.67,一至六個月24.07±9.25,七至十八個月12.49±4.54,二至三歲3.21±1.51,七至九歲3.29±1.13,十一至十四歲2.68±1.01,成人2.84±1.25u/g creatinine。十三位臨床診斷為腎盂腎炎之病童,其治療前之尿中NAG值顯著高於正常值(p<0.001),其中十一位治療前之平均NAG值為109.82±87.30u/g creatinine,停藥後及治療完成二至四星期後之值分別為75.26±48.82及15.37±9.69u/g creatinine,此結果顯示腎盂腎炎造成腎小管細胞之傷害,因此尿中NAG可望用來分別上、下泌尿道感染之診斷。 |
英文摘要 | Urinary excretion Of N-acetyl-beta-glucosaminidase (NAG) was measured in random urine as the ratio of NAG to grams of urinary creatinine in 120 normal Chinese children. The results showed that the NAG was elevated in newborn babies and infants, and decreased to adult level after two years of age. Thirteen children with urinary tract infection, who were clinically suggested or proved to have pyelonephritis, were evaluated for their urinary NAG excretion. The level of enzymuria at diagnosis in these patients was significantly higher than that of normal children for age. Eleven longitudinal follow-up data including levels at diagnosis, end of treatment, and two to four weeks after treatment showed that the mean urinary NAG at diagnosis was 109.82±87.30 u/g creatinine, compared with 75.26±48.82 u/g creatinine at the end of treatment and 15.37±9.69 u/g creatinine after recovery. These data suggest the presence of renal tubular cell injury in upper urinary tract infection. Thus urinary NAG may play a role in differentiating lower from upper urinary tract infections. |
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