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頁籤選單縮合
題名 | Urinary N-Acetyl-Beta-Glucosaminidase in Children With Acute Renal Failure=急性腎衰竭孩童之尿中N-acetyl-beta-glucosaminidase (NAG) 活性 |
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作者 | 曹永魁; 陳炯暉; 楊麗芳; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷期 | 33:1 民81.01-02 |
頁次 | 頁5-11 |
分類號 | 415.5742 |
關鍵詞 | 尿; 孩童; 急性; 活性; 腎衰竭; |
語文 | 英文(English) |
中文摘要 | 本研究尿中NAG活性以NAG和每公克肌酸酐之比值表示,對16位臨床上為急性腎小管壞死的急性腎衰竭孩童及8位有過缺氧或潛在性腎毒性傷害,但並無血中肌酸酐變化的病童,測定尿中NAG的變化。臨床上無急性腎衰竭的孩童,其尿中NAG於腎傷害前後呈現有意義的增加(P<0.001),而在2星期內均回復正常;和各年齡層之正常平均值比較,這些孩童尿中NAG有6.4±1.4倍的增加。而在急性腎衰竭的孩童,最高血中肌酸酐之平均值爲3.6±2.0 mg/dl,平均回復期8.8±4.1天(n=13,3位病人死亡);尿中NAG於急性期非常顯著增高,於血中肌酸酐回復正常時仍持續不降,甚至於在數星期後仍未降至正常;和正常值比較,平均升高34.3±24.7倍,與前者無腎衰竭孩童呈有意義的差別(P<0.01)。此結果提供我們可能有用的臨床建議,也許尿中NAG升高的程度可用來監視有潛在腎毒性危險病童急性腎衰竭之發生。 |
英文摘要 | Urinary excretion of N-acetyl-beta-glucosaminidase (NAG) was measured in random urine as the ratio of NAG to grams of urinary creatinine. Sixteen children with acute renal failure as well as 8 patients without serum creatinine changes after ischemic insults or nephrotoxic hazards were evaluated for their urinary NAG excretion. For children without renal failure, there was a significant increase (p<0.00l) in urinary NAG after insults. The urinary NAG returned to normal within 2 weeks. In children with acute renal failure, the mean peak serum creatinine was 3.6±2.0 mg/dl, and the mean duration between onset and the time serum creatinine returning to normal was 8.8±4.1 days. Urinary NAG was markedly elevated during acute azotemic stage, remained at high level (p>0.05) after serum creatinine returning to normal, and even continued to be abnormal several weeks after clinical recovery. Corrected with age, the mean urinary NAG level was elevated 6 times above normal after insults in patients without renal failure, and 34 times greater than normal in children with acute renal failure (p<0.01). We suggest that the extent of elevation of urinary NAG may be used to monitor the development of acute renal failure in patients exposed to potentially nephrotoxic hazards. |
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