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題名 | Test Heterogeneity of the Lupus Anticoagulant (LA): Comparison of Various LA Tests in 102 Cases of Systemic Lupus Erythematosus=狼瘡性抗凝物(LA)試驗之差異性:在102個全身性紅斑性狼瘡病例中比較不同的LA試驗 |
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作者 | 何照洪; 周永強; 徐會棋; 蔡世滋; | 書刊名 | 醫學研究 |
卷期 | 18:5 1998.03[民87.03] |
頁次 | 頁297-305 |
分類號 | 415.695 |
關鍵詞 | 試驗之差異; 狼瘡性抗凝物; 狼瘡性抗凝物試驗; 全身性紅斑性狼瘡; Test heterogeneity; Lupus anticoagulant; Lupus anticoagulant tests; Systemic lupus erythematosus; |
語文 | 英文(English) |
中文摘要 | 用五種不同之試劑包括Staclot PNP, Staclot LA,PTT-LA和兩種dilute Russell's viper venom time tests,偵測102位全身性紅斑性狼瘡(SLE)病人之lupus anticoagulant。這五種試驗有不同的陽性率,範圍為4到9%,而且病人在不同的試驗有不同的結果。若以病人有兩項或兩項以上的LA試驗呈現陽性,則作為陽性時,在本研究中有8%的SLE病人為LA陽性。在這五種LA試驗,DVV試驗與LA-Screen & LA-Confirm有最高的相關性(k=0.648)。而與任何其他四種試驗有最高相關性的試驗則為Staclot LA,其相關性為(k=O.864)。由於LA試驗結果的差異性,如果病人只有一種LA試驗為陽性,則要小心診斷是否有LA。 |
英文摘要 | Five commercial kits including Staclot PNP, Staclot LA, PTT-LA, and 2 dilute Russell's viper venom time tests for detecting lupus anticoagulant were determined in 102 patients with systemic lupus erythematosus (SLE). The 5 coagulation tests had different positive rates ranging from about 4 to 9%, and the patients might have different result by using different test. If we regarded a patient with two or more positive LA tests as being positive, 8% of the SLE patients in our study were LA positive. Among the 5 LA tests, the highest correlation was between DVVtest and LA-Screen & LA-Confirm (k =0.648), and the test having the highest correlation with the remaining other 4 tests was Staclot LA (k=0.864). The consistency of LA tests and anti-cardiolipin antibody test was good. Due to the heterogeneity of the results of LA tests, the diagnosis of the presence of LA in a patient should be carefully made if only one LA-positive test was obtained. |
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