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題 名 | Elevated Interleukin-10 Levels Correlate with Disease Activity in Systemic Lupus Erythematosus=全身性紅斑性狼瘡介白質-10之升高和其疾病活動度呈相關性 |
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作 者 | 黃春明; 陳季蘭; | 書刊名 | 中臺灣醫學科學雜誌 |
卷 期 | 5:1 2000.03[民89.03] |
頁 次 | 頁37-42 |
分類號 | 415.695 |
關鍵詞 | 疾病活動度; 介白質-10; 全身性紅斑性狼瘡; Disease activity; Interleukin-10; Systemic lupus erythematosus; |
語 文 | 英文(English) |
中文摘要 | 背景:偵測全身性紅斑性狼瘡患者血清中介白質﹣10之濃度及分析其和疾病活動度之相關性。 方法:本研究對象為50位全身性紅斑性狼瘡患者,並以30位正常人為對照組。使用方法是以介白質﹣10和全身性紅斑性狼瘡疾病活動度指標(SLEDAI)及實驗室數據如補體(C3和C4)、抗DNA抗體、免疫球蛋白G、免疫球蛋白M和免疫球蛋白A加以比較。 結果:全身性紅斑性狼瘡患者介白質﹣10濃度在統計學上顯著地高於正常人(34.3 ±7.2比 5.8 ± 1.2 pg╱ml,p<0.05)。介白質﹣10和SLEDAI(r=0.42,p<0.01)及抗DNA抗體(r= 0.1,p<0.05)呈現正相關性。而與C3卻為負性相關性(r=-0.45,p<0.01)。然而,介白質﹣10與C4在統計學上並無相關性。 結論:本研究顯示在全身性紅斑性狼瘡患者介白質﹣10會有較高之濃度,且介白質﹣10和患者之疾病活動度具有相關性。 |
英文摘要 | BACKGROUND: We analyzed the relationship between serum interleukin IL)-10 levels and disease activity in patients with systemic lupus erythematosus (SLE). METHODS: The study enrolled 50 SLE patients and 30 healthy adults who were used as the control group. The IL-10 levels in the serum were determined and compared according to disease activities, which were measured using the SLE Disease Acitivty Index (SLEDAI) and laboratory parameters such as C3, C4, anti-dsDNA antibodies, IgG, IgM and IgA. RESULTS: The IL-10 levels of the SLE patients were significantly higher than those of the control group (34.3 ± 7.2 vs 5.8 ± 1.2 pg/ml, p<0.05). Serum IL-10 titers in SLE patients positively correlated with the SLEDAI (r=0.42, p<0.01) and anti-dsDNA antibodies (r=0.3, p<0.05), but negatively correlated with complement C3 levels (r=-0.45, p<0.01). However, there was no significant association between IL-10 and C4 levels. CONCLUSIONS: Our study demonstrated that serum levels of IL-10 were elevated in SLE patients and increased IL-10 correlated with SLE disease activity. |
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