查詢結果分析
相關文獻
- Effects of Dobutamine on Circulatory Failure and Survival in Rats with Endotoxemia
- Combined Effects of Dexamethasone and Aminoguanidine on Rats with Endotoxemia
- Beneficial Effects of Tetramethylpyrazine, an Active Constituent of Chinese Herbs, on Rats with Endotoxemia
- 芝麻油對脂多醣所引發之肝臟傷害的保護
- 兒茶素補充可避免脂多醣誘發大白鼠低血壓反應
- Lipopolysaccharide-stimulated Leukocytes Contribute to Platelet Aggregative Dysfunction, Which is Attenuated by Catalase in Rats
- Nitro変-L-Arginine Methyl Ester Decreases Minimum Alveolar Concentration of Isoflurane and Reduces Brain Nitric Oxide Synthase Activity in Rats
- 長期阻斷內生性一氧化氮對血壓的影響:正常鼠與高血壓鼠間的比較
- 使用吸入性一氧化氮(NO)治療成人呼吸窘迫症(ARDS):利?或弊?
- Altering Sphingomyelin Signaling in Vessels from Stroke-prone Spontaneously Hypertensive Rats
頁籤選單縮合
題 名 | Combined Effects of Dexamethasone and Aminoguanidine on Rats with Endotoxemia=Dexamethasone與Aminoguanidine在內毒性休克鼠的混合療法 |
---|---|
作 者 | 吳錦楨; 顏茂雄; | 書刊名 | Proceedings of the National Science Council : Part B, Life Science |
卷 期 | 22:1 1998.01[民87.01] |
頁 次 | 頁39-45 |
分類號 | 418.1 |
關鍵詞 | 內毒素; 一氧化氮; Dexamethasone; Aminoguanidine; Nitric oxide; Lipopolysaccharide; Endotoxic shock; |
語 文 | 英文(English) |
中文摘要 | 本論文研究 dexamethasone ( DEX,一種誘導型一氧化氮合成酵素生成抑制劑) 合併 aminoguanidine ( AG, 一種誘導性一氧化氮合成酵素活性抑制劑)對大鼠經內毒素 處理後各種症狀之療效。同時也檢視假如完全抑制一氧化氮的形成是否具有改善內毒素所引 起的低血壓、血管低反應性和存活率。實驗結果顯示,大鼠經內毒素處理後會引起血壓下降 、心跳增快和血管的低反應性,而且血中一氧化氮的濃度持續性上升。DEX 與 AG 前後給予 的混合療法可以完全抑制因內毒素所引起的一氧化氮過量生成, 並改善遲緩性低血壓, 但卻 會加強心跳過快的現象; 然而對內毒素所引起的血管低反應性只有部份改善。最後整體的結 果顯現出此種混合療法可以提高動物的存活率。 這些結果暗示著 (1) 這種混合療法可改善 內毒素所引起的部份致命作用;(2) 一氧化氮只是引起敗血性休克時血管低反應性的因素之 一。 |
英文摘要 | The effects of a combination of dexamethasone (DEX, an inhibitor of inducible nitric oxide synthase (iNOS) synthesis) and aminoguanidine (AG, an inhibitor of iNOS activity) on the anesthetized rat treated with endotoxin (lipopolysaccharide, LPS) were examined. In addition, we investigated whether a complete inhibition of nitric oxide (NO) formation caused by LPS prevents the hypotension, restores the vascular hyporeactivity to normal and improves the survival rate. The combination of DEX (3 mg/kg at 30 min prior to LPS) plus AG (15 mg/kg at 2 h after LPS) inhibited the overproduction of nitrate (an indicator of NO) and prevented the development of delayed hypotension, but further enhanced tachycardia in rats treated with LPS for 6 h. In addition, the vascular hyporeactivity to norepinephrine (NE) was, however, only partially restored in endotoxemic rats treated with DEX plus AG. During the experimental period, the survival rate of LPS-rats treated with DEX plus AG was also improved when compared to that of rats treated with LPS only. The beneficial effects of the combined therapy with DEX plus AG on rats with endotoxemia, suggesting that (i) combined treatment of animals with DEX plus AG may reduce some of the detrimental effects of LPS and (ii) NO only partially contributes to the vascular hyporeactivity in endotoxic shock. |
本系統中英文摘要資訊取自各篇刊載內容。