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題 名 | Effects of Dobutamine on Circulatory Failure and Survival in Rats with Endotoxemia=Dobutamine對內毒素性鼠的循環性衰竭和存活率的影響 |
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作 者 | 廖美惠; 吳錦楨; | 書刊名 | 醫學研究 |
卷 期 | 20:8 2000.10[民89.10] |
頁 次 | 頁416-428 |
分類號 | 418.217 |
關鍵詞 | 腫瘤壞死因子; 一氧化氮; 存活率; 內毒素性休克; Dobutamine; Tumor necrosis factor-α; Nitric oxide; Survival; Endotoxic shock; |
語 文 | 英文(English) |
中文摘要 | Dobutamine(一種乙一型交感神經接受器致效劑)輸注至敗血性休克病人可增加其全身氧氣輸送至缺氧組織,故推測可用來治療敗血性休克病人。然而,有關dobutamine在敗血性休克的療效報告至今仍尚未有定論。這個研究在評估內毒素性鼠經dobutamine治療後是否可改善其循環性衰竭。Dobutamine(10微克/公斤/分鐘)同時與E. coli內毒素(脂多醣;10毫克/公斤)注射至麻醉鼠。另外,作一組手術的時間控制組用來作對照。動物經脂多醣注射後引起(一)體溫和血糖呈一鐘型變化,(二)血壓雙相降低作用和心跳顯著上升,(三)對新腎上腺素(1微克/公斤)產生嚴重的低反應性,(四)血漿中腫瘤壞死因子和一氧化氮濃度顯著增加,和(五)實驗期間83%的存活率。給予內毒素性鼠dobutamine的治療更加強高體溫,後期低血壓,心跳增快,對新腎上腺素產生血管低反應性,和死亡率增加。相反地,dobutamine可抑制最高腫瘤壞死因子濃度和早期一氧化氮濃度,但對血糖並無顯著地影響。我們的結果暗示著在病人(至少在動物)患有敗血性休克時使用dobutamine來治療應特別小心。 |
英文摘要 | Dobutamine (a β1-adrenergic receptor agonist) infusion is used to increase whole-body oxygen delivery in septic patients to satisfy unmet oxygen demand of hypoxic tissues and had been suggested to treat patients with septic shock. However, the beneficial effect of dobutamine on septic shock remains controversial. This study was to reexamine whether dobutamine exerts benefits by evaluating the circulatory changes in rats with endotoxic shock. Dobutamine (10μg/kg/min) was administered to the anesthetized rat simultaneously with the injection of Escherichia coli endotoxin (lipopolysaccharide, LPS; 10 mg/kg, i.v.). A group of sham-operated time-control rats was also performed. The injection of LPS caused (i) a bell-shape change of temperature and blood glucose, (ii) a biphasic decrease of blood pressure and a significant tachycardia, (iii) a severe vascular hyporeactivity to norepinephrine (NE; 1μg/kg, i.v.), (iv) a significant increase of tumor necrosis factor-α (TNF-α) and nitrate (an indicator of nitric oxide) in plasma, and (v) a survival rate of 83% during the experimental period. The treatment of LPS rats with dobutamine further enhanced the hyperthermia, the delayed hypotension, the tachycardia, the vascular hyporeactivity to NE, and the lethality. In contrast, dobutamine surpressed the peak level of TNF-α and the early increase of nitrate level in plasma, whereas it had no significant effect on the blood glucose level elicited by LPS. Our results indicate that the uses of dobutamine in animals, at least, or in humans with septic shock should be cautious. |
本系統中英文摘要資訊取自各篇刊載內容。