查詢結果分析
來源資料
相關文獻
- Modulation of Activated Murine Peritoneal Macrophages Functions by Emodin, Aloe-emodin and Barbaloin Isolated from Aloe Barbadensis
- Determination of Marked Components--Aloin and Aloe-emodin--in Aloe Vera before and after Hydrolysis
- 大花咸豐草不同萃取方式之抗發炎及抗氧化活性
- 食品中蘆薈素及蘆薈大黃素檢驗方法評估
- 大黃抑制幽門螺旋桿菌及其作用機轉之研究
- 冠心病患者經皮冠狀動脈腔內成形術後腫瘤壞死因子和一氧化氮的變化及意義
- Effects of Six Anti-Inflammatory Chinese Herbs on LPS/IFN-γ-Induced Nitric Oxide Production in RAW264.7 Macrophages
- Effects of Dobutamine on Circulatory Failure and Survival in Rats with Endotoxemia
- The Roles of Pain Facilitatory Systems in Opioid Tolerance
- 以細胞模式篩選抗發炎藥物分析平臺之建立:以蛇床子素為例
頁籤選單縮合
題 名 | Modulation of Activated Murine Peritoneal Macrophages Functions by Emodin, Aloe-emodin and Barbaloin Isolated from Aloe Barbadensis=蘆薈萃取物(大黃素、蘆薈大黃素及蘆薈素)對調節活體小鼠腹膜巨噬細胞活性之探討 |
---|---|
作 者 | 方世華; 詹如; 蔡新聲; | 書刊名 | 藥物食品分析 |
卷 期 | 14:1 2006.03[民95.03] |
頁 次 | 頁7-11+94 |
分類號 | 414.5 |
關鍵詞 | 庫拉索蘆薈; 百合科; 大黃素; 蘆薈大黃素; 蘆薈素; 腫瘤壞死因子; 一氧化氮; 抗發炎; 脂多糖; Aloe barbadensis; Liliaceae; Emodin; Aloe-emodin; Tumor necrosis factor; Nitric oxide; Anti-inflammatory activity; Lipopoly-saccharide; |
語 文 | 英文(English) |
中文摘要 | 在活體小鼠腹膜巨噬細胞發炎系統中,一氧化氮合成酵素(inOs)是一個重要的指標物質。本研究發現從庫拉索蘆薈萃取出來三個重要成分:大黃素、蘆薈大黃素及蘆薈素,在老鼠巨噬細胞、脂多糖(lPs)及干擾素-(IFn-)所組成的發炎系統中,可以抑制系統所產生的一氧化氮(nO)、腫瘤壞死因子(tnF-α)和白血球間質素-12(Il-12)。 結果顯示,大黃素、蘆薈大黃素及蘆薈素分別在濃度120,30 and 200mM時,可以抑制一半濃度(IC50)的nO、tnF-α和Il-12。此外,也發現大黃素可以抑制發炎反應前期(pretreated lPs/IFn-)以及發炎反應後期(post-lPs/IFn-)nO的量。蘆薈大黃素以及蘆薈素可以抑制發炎反應前期nO的量。純化的化學物質鑑定由核磁共振儀(nMR)、質譜儀(massspectral)以及沸點測定。 |
英文摘要 | Activated murine macrophages produce high level of nitric oxide by inducible nitric oxide synthase (iNOS), which is an important mechanism in macrophage-induced inflammation. In the present study, we isolated emodin, aloe-emodin and barbaloin compounds from Aloe barbadensis and investigated their inhibitory effects on the production of nitric oxide (NO), tumor necrosis factor-α (TNF-α) and interleukin (IL-12) from murine macrophages activated by lipopolysaccharide (LPS) and interferon-gamma (IFN-γ). Our results showed that the 50% inhibition concentration (IC50) of emodin, aloe-emodin and barbaloin on NO, TNF-α and IL-12 from activated peritoneal macrophages were 120, 30 and 200 µM respectively. Our experimental results showed that reduction of NO level by emodin might inhibit both at the pretreated LPS/IFN-γ activation and post-LPS/IFN-γ activation pathway. Activities of aloe-emodin and barbaloin could be caused by inhibition at the pretreated LPS/IFN-γ activation event. Chemical structures of all the isolated components were identified by comparison of NMR, mass spectral data and melting points with those reported in literature. |
本系統中英文摘要資訊取自各篇刊載內容。