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題 名 | Sources of Superoxide Radicals Involved in the Pathogenesis of Diethyldithiocarbamate-Induced Gastric Antral Ulcer in Rats=DDC引發大白鼠胃前庭潰瘍機轉中超氧自由基之可能來源 |
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作 者 | 陳盛煊; 潘憲; | 書刊名 | 臺灣醫學會雜誌 |
卷 期 | 97:2 1998.02[民87.02] |
頁 次 | 頁131-134 |
分類號 | 415.121 |
關鍵詞 | 大白鼠; 胃前庭潰瘍機轉; 超氧自由基; DDC; Gastric ulcer; Superoxide radical; Superoxide dismutase; Platelet-activating factor; Neutrophil; |
語 文 | 英文(English) |
英文摘要 | The production of superoxide radicals as a result of decreased Cu, Zn- superoxide dismutase activity is considered to be the most important factor in the pathogenesis of diethyldithiocarbamate (DDC)-induced gastric antral ulcers in rats. The aim of the present study was to identify possible sources of superoxide radicals and the role of platelet-activating factor (PAF) in DDC-induced ulcer formation. Groups of rats were pretreated with a drug or antiserum before DDC (800 mg/kg) administration. The size of the DDC-induced gastric antral ulcers was measured. Pretreatment with anti-rat polymorphonuclear leukocyte serum or CV-3988 (a specific antagonist of PAF)20 mg/kg significantly reduced the size of DDC-induced gastric antral ulcers. The results confirmed that superoxide radicals play an important role in the pathogenesis of DDC-induced gastric ulcer in rats and suggested that NADPH (reduced nicotinamide-adenine dinucleotide phosphate) oxidase in PAF-activated polymorphonuclear leukocytes may be involved in the generation of these radicals. |
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