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題名 | 芍藥不同炮炙品及芍藥甘草湯鎮痛、鎮靜、解熱作用與活性成分含量變化之研究=A Study in the Analgesic, Sedative and Antipyretic Effects of Various Preparations of Paeoniae Alba Radix and Shao-Yao-Kan-Tsao-Tang |
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作者姓名(中文) | 謝明村; 林穎志; 彭文煌; 蔡輝彥; 張光雄; 陳介甫; | 書刊名 | 中國醫藥學院雜誌 |
卷期 | 6:3 1997.12[民86.12] |
頁次 | 頁151-162 |
分類號 | 414.4 |
關鍵詞 | 芍藥炮炙品; 芍藥甘草湯; 鎮痛; 鎮靜; 解熱; Preparations of paeoniae alba radix; Shao-Yao-Kan-Tsao-Tang; Analgesia; Sedation; Antipyretic effect; |
語文 | 中文(Chinese) |
中文摘要 | 本研究以藥理方法(pentobarbital 誘發睡眠,醋酸扭體法,福馬林試驗,中樞 神經興奮劑引起之痙攣試驗,LPS 誘發高溫)探討芍藥不同炮炙品(生品、醋炙、酒炙、麩 炒炙)及其與炙甘草組成之芍藥甘草湯之鎮靜、鎮痛、抗痙攣、解熱及降溫等藥理作用之差 異性,並以高效液相層析法( HPLC )測定芍藥不同炮炙品及其與炙甘草組成之芍藥甘草湯 中所含主成分(芍藥甘、丹皮酚)之含量變化,藉以瞭解芍藥炮炙品對芍藥甘草湯之藥理作 用與主成分含量變化之關係。實驗結果顯示,芍藥各炮炙品及其與炙甘草組成之芍藥甘草湯 均可延長 pentobarbital 誘發之睡眠時間, 生品、醋炙品及酒炙品芍藥及芍藥各炮炙品與 炙甘草組成之芍藥甘草湯對醋酸扭體次數有明顯抑制作用;醋炙品及酒炙品芍藥及生品、醋 炙品及酒炙品芍藥甘草湯對福馬林試驗之前期舔足時間有抑制作用,芍藥不同炮炙品及生品 、醋炙品及酒炙品芍藥甘草湯對正常大鼠體溫有降溫效果,醋炙、酒炙及麩炒炙品芍藥和醋 炙及酒炙芍藥及酒炙芍藥甘草湯對正常大鼠體溫有降溫效果,醋炙、酒炙及麩炒炙品芍藥和 醋炙及酒炙芍藥甘草湯對 LPS 誘發之高溫有明顯抑制作用; 醋炙品及酒炙品芍藥及醋炙品 及酒炙品芍藥甘草湯對 strychnine 誘發陣發性痙攣時間有明顯延長作用。高效液相層析法 分析芍藥不同炮炙品及其與炙甘草組成之芍藥甘草湯中芍藥甘、丹皮酚或甘草酸之含量變化 ,結果顯示以醋炙與酒炙品含量最高,依次是生芍藥與麩少炙芍藥,且複方之主要成分含量 皆比單味為高。綜合以上結果,顯示芍藥各炮炙品及其與炙甘草組成之芍藥甘草湯中,以醋 炙及酒炙品之鎮靜、鎮痛、抗痙攣、降溫及解熱效果最好,主成分含量最高,臨床使用上應 以醋炙及酒炙為佳。 |
英文摘要 | In the present study, we investigated the sedative, nalgesic, antipyretic and hypothermic effects of various preparations of Paeoniae Alba Radix(PAR, PARa, PARb and PARc) and Shao-Yao-Tsao-Tang(SKT, SKTa, SKTb, SKTc)on hyponsis induced by pentobarbital, writhing response induced by acetic acid, formalin test, and feve rinduced by LPS. We also detected contents among major active constituents (paeoniflorin, paeonol) of various Paeoniae alba radix and Shao-Yao-Kan-Tsao-Tang.The result indicated that various preparations of paeoniae Alba Radix and Shao-Yao-Kan-Tsao-Tang prolonged the sleeping time induced by pentobarbital.PARPARa, PARb and various preparations of Shao-Yao-Kao-Tsao-Tang.The result inhibited the writhing response induced by acetic acid. PARa, PARb and various preparations of SKT shortened the feet-licking time of mice in the late phase of the formalin test. Various preparations of Paeoniae Alba Radix,SKT SKTa and SKTb exerted a hypothermic effect in normal rats. In the HPLC analysis, contents of paeoniflorin and paeonol found in PARa, PARb, SKTa and SKTb were higherwere higher than those of PAR, PARc, SKT and SKTc. Likewise, the content amounts of paeoniflorin and paeonol were also higher in Shao-Yao-Kan-Tsao-Tang, as compared to Paeoniae Alba Radix. In conclusion, alcohol and acetic acid preparations of Paeoniae Alba Radix and Sho-Yao-Tsao-Tang possessed stronger sedative, analgesic, hypothermic and antipyretic effects than other preparations. They consisted a higher content of the major active consttsuents. Paeoniflor in and paeonol could be the active constituents in Pae-oniae Alba Radix and Sho-Yao-Tsao-Tang. |
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