頁籤選單縮合
題名 | 過山龍(Vernonia Gratiosa Hance)解熱鎮痛作用之研究=Antipyretic and Analgesic Effects of "Vernonia Gratiosa Hance" |
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作者 | 尤紹懿; 闕甫伃; 邵立珠; 張永勳; | 書刊名 | 中國醫藥科學雜誌 |
卷期 | 1:4 2000.12[民89.12] |
頁次 | 頁283-291 |
分類號 | 418.5 |
關鍵詞 | 過山龍; 解熱; 鎮痛; Vernonia gratiosa hance; Antipyresis; Analgesia; |
語文 | 中文(Chinese) |
中文摘要 | 過山龍 (Vernonia gratiosa HANCE),一名斑鳩菊,為菊科斑鳩菊屬植 物,台灣民間常用之解熱鎮痛藥物,但迄今仍無相關研究提出,因此本研究即針 對過山龍解熱鎮痛之作用進行評估。結果顯示,使用過山龍甲醇萃取物 (0.5~2g/kg, i.p.),在室溫下對細菌內毒素 lipopolysaccharide (LPS) 誘發發燒之大 鼠,具有明顯及劑量依存性之解熱作用;在0.1~2g/kg (i.p.) 劑量下,對內生性致 熱原 IL-1b 誘發之發燒反應亦具有抑制作用。從醋酸扭體實驗及福馬林試驗之 結果顯示,過山龍之甲醇萃取物具有顯著的鎮痛作用;在較大劑量 (3g/kg i.p.) 時,幾乎可以完全抑制醋酸所造成的扭體次數,而對福馬林引起疼痛之前期具明 顯之抑制作用,對後期則需於較大劑量 (2g/kg i.p.) 才有作用。綜合實驗結果, 過山龍確具有解熱、鎮痛之作用。 |
英文摘要 | Vernonia gratiosa Hance of the Compositae Family is a traditional native medicine in Taiwan, which has been used to clear away heat, activate blood circulation and relieve swelling and pain. In our present study, the methanolic extracts of V. gratiosa were evaluated for antipyretic and analgesic effects in rats or mice. In unanesthetized rats, V. gratiosa (0.5~2 g/kg, i.p.) caused a dose-related fall in colonic temperature at room temperature (24±1 °C). The fever induced by either lipopolysaccharide ( LPS, 100 mg/kg, i.p.) or interleukin-1b (10ng/10ml, lateral cerebral ventricle injection) was attenuated by treatment using V. gratiosa (0.1~2g/kg i.p.) in rats. Methanlic extract of V. gratiosa inhibited the writhing response induced by acetic acid and the early and late phase pain responses induced by formalin in mice (i.p.), respectively. These results indicated that V. gratiosa posses both antipyretic and analgesic effects. |
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