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題名 | Fuzzy Logic Control of Propofol Infusion Using Quantitative and Qualitative Approaches |
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作者 | Shieh,Jiann-shing; Chang,Liang-wey; Fan,Shou-zen; Liu,Chien-chiang; | 書刊名 | 醫學工程 |
卷期 | 9:6 1997.12[民86.12] |
頁次 | 頁24-36 |
分類號 | 416.5 |
關鍵詞 | 層級結構; 模糊邏輯控制; 靜脈麻醉劑; Hierarchical structure; Primary depth of anaesthesia; Pharmacokinetic model; Propofol concentration; Propofol infusion rate; |
語文 | 英文(English) |
英文摘要 | A two-level hierarchical structure using quantitative and qualitative approaches for controlling propofol infusion rate is proposed in this paper. The first level merges on-line measurements (i.e. systolic arterial pressure (SAP) and heart rate (HR)) to interpret the primary depth of anaesthesia (PDOA) using fuzzy logic which is purely qualitative approach. The second level uses an average three-compartment pharmacokinetic model to predict the propofol concentration (PC) in the blood of the patient which is entirely quantitative approach. Then, using fuzzy set theory to combine these two levels, a lookup table to administer the propofol infusion rate (PIR) is obtained. This lookup table, not only based on the patient's pharmacokinetic model of the propofol but also based on the patient's clinical feedback signals of SAP and HR, has given confidence of anesthesiologists to perform automatic control of propofol in clinical trials at the next stage. |
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