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題名 | Propofol-Sodium Thiopental Admixture Reduces Pain on Injection=Propofol與Sodium Thiopental 混合可減輕Propofol注射時的疼痛 |
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作者姓名(中文) | 高宜娟; 吳世銓; 鄭嘉遜; | 書刊名 | 麻醉學雜誌 |
卷期 | 38:1 2000.03[民89.03] |
頁次 | 頁9-13 |
分類號 | 416.5 |
關鍵詞 | 靜脈麻醉劑; 疼痛; 靜脈注射; Anesthetics; Intravenous; Sodium thiopental; Propofol; Pain; Injection; Intravenous; |
語文 | 英文(English) |
中文摘要 | Background: Propofol injection associated with a high incidence of pain is well knowen. Propofol and sodium thiopental mixture has recently been reported to be used for cost saving and able to reduce pain on injection. Methods: This prospective, randomized, double blind trial was designed to compare the efficacy of different percentages of propofol and sodium thiopental mixture in minimizing propofol injection pain. 146 ASA clas 1 patients were assigned to seven groups (pure propofol, pure sodium thiopental, and propofol premixed with 10%, 20%, 30%, 40%, and 50% of sodium thiopental). The instensity of pain was graded and recorded as severe, moderate, mild and no pain according to the response of the patients to the injection. Results: The intensity of injection pain was significantly greater for pure propofol than the others while it was not significantly different among the other groups in comparison. Conclusions; sodium thiopental, when added to propofol, can significantly reduce propofol injection pain. This attenuation effect was noted even with as low as 10 volume % of sodium thiopental. |
英文摘要 | 背景:Propofol在注射時常導致疼痛。近來曾有報告指出propofol 與 sodium thiopental混合注射用於節省成本並能減少疼痛。 方法:利用隨機雙盲實驗來比較不同比例的propofol與sodium thiopental混合劑注射時產 生疼痛的程度。將146位ASA class I的病人分成7組(純propofol、純sodium thiopental、 propofol分別混以10%、20%、30%、40%和50%容積比例之 sodium thiopental溶液),根據 病人在注射藥物時的反應分成很痛、中度痛、輕微病、和不痛四種程度紀錄。 結果:純propofol注射時產生的疼痛遠超過其他6組配方。但改變sodium thiopental的比 例對於疼痛的改善無差異。 結論:sodium thiopental 和 propofol 混合即可減輕注射時疼痛。即使只加10% 容積的 sodium thiopental 仍有減少 propofol 注射時疼痛的效果。 |
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