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題 名 | Comparison of Intravenous Retention of Fentanyl and Lidocaine on Local Analgesia in Propofol Injection Pain=比較靜脈內存留Fentanyl與Lidocaine能減少Propofol注射引起疼痛的效果 |
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作 者 | 龐維伍; 黃玄; 鍾雍泰; 張大鵬; 林世祥; 黃明和; | 書刊名 | 麻醉學雜誌 |
卷 期 | 35:4 1997.12[民86.12] |
頁 次 | 頁217-221 |
分類號 | 416.5 |
關鍵詞 | 麻醉劑; 靜脈內:Propofol; 麻醉劑; 局部性:Lidocaine; 止痛劑; 類鴉片製劑:Fentanyl; 疼痛:靜脈注射; Anesthetics; Intravenous:Propofol; Anesthetics; Local:Lidocaine; Analgesics; Opioid:Fentanyl; Pain:Injection; Intravenous; |
語 文 | 英文(English) |
中文摘要 | 背景:靜脈內存留lidocaine 60毫克有效地防止propofol之注射痛,但fentanyl 對此種週邊之作用尚未比較過。 方法:112位麻醉體位1和2之病患分成三組,在上臂綁上靜脈止血帶後:A組(n=38)靜脤 注入生理鹽水3西西,B組(n=37)注入fentany1 3西西,C組(n=37)組注入2% lidocaine 3 西西.在一分鐘後放開止血帶,開始以propofol100毫克引導麻醉。 結果:在B和C組之病患都比A組較少有propofol之注射痛(p<0.005)。Lidocaine 60 毫克之效果最好,fentany1 3西西 or 150 μg雖然較xylocaine為差,但Fentany1 3西西 也有較生理鹽水強之效果(p<0.005)。Fentanyl靜脈內存留之副作用包括28%病患有短暫(一 分鐘內)之注射痛及14%病患有暫時性(兩小時內)輕微之局部皮膚發紅。Lidocaine只有2%病 患有短暫(一分鐘內)之注射痛而無其他之副作用。 結論:在靜脈內存留一分鐘,fentany1 3西西之止痛作用較2% 1idocaine 3西西為差, 亦有較多的副作用,本文對fentanyl之局部止痛作用加以探討。 |
英文摘要 | Background: With a tourniquet on arm for arresting venous blood flow, we evaluated the efficacy of intravenous (IV) retention of fentanyl and lidocaine in reducing the pain on IV propofol injection during general anesthesia. Methods: One hundred and twelve patients were studied. Following a venous occlusion by a tourniquet inflated to 70 mmHg, patients in Group A (n = 38) received normal saline (NS) 3 ml, while those in Group B (n = 37) and in Group C (n =37) respectively received fentanyl 150 μ g or 3 ml and 2% lidocaine 3 ml (60 mg). The venous retention of drug was maintained for 1 min, followed immediately by tourniquet release and propofol 100 mg IV injection over 20 s. Results: Both fentanyl and lidocaine treatments (Groups B and C) were significantly better than placebo (Group A) in reducing pain on propofol injection (p <0.005). Lidocaine 60 mg was more effective than fentanyl 150μg in reduction of pain associated with IV propofol (p < 0.001). Injection of fentanyl itself caused pain in 28% of patients as compared to 2% in the lidocaine group. Mild local skin erythema was noted in 14% of patients with fentanyl venous retention versus 0% of patients with lidocaine venous retention. Conclusions: Intravenous retention of fentanyl 150μg, although less effective than that of lidocaine (p < 0.001), showed local analgesic effect in reducing the pain on propofol injection. The hypothetic mechanisms of action were speculated. |
本系統中英文摘要資訊取自各篇刊載內容。