頁籤選單縮合
題名 | 免疫調節方劑之研究(1)--補血、補氣方劑=Studies on Immunoregulation of Chinese Prescription(Ⅰ)--Replenishing the Vital Essence Prescription |
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作者 | 梁文俐; 楊玲玲; | 書刊名 | 臺灣科學 |
卷期 | 50:2 1997.12[民86.12] |
頁次 | 頁1-15 |
分類號 | 413.4 |
關鍵詞 | 中藥方劑; 免疫系統; 抗體力價; T淋巴細胞及其亞群細胞; 協助性T細胞/抑制性T細胞比價; Chinese prescriptions; Immunity system; Antibody titer; T lymphocyte and subclass of T cells; Th/Ts ratio; |
語文 | 中文(Chinese) |
中文摘要 | 傳統之中國醫藥無論在過去,還是未來在醫藥史皆具有相當的貢獻,對免疫學發 展亦將有很大的影響,尤其近年來陸續發現其醫療效果與免疫機制有相當的關係。中醫認為 疾病是人體正氣被病邪削減或抑制之結果所致,因此正氣之強弱乃決定於疾病之發生與否? 中國醫學中治療疾病用藥有所謂之「扶正袪邪」,法則,即針對此而發,具有「扶正祛邪」 作用之藥物,即包含了傳統中藥中之補益方劑,其即作用於免疫系統,以發揮其防治作用。 本研究選擇〞中藥補益〞方劑 - 參苓白朮散、四君子湯、 四物湯、清暑益氣湯、人參養榮 湯等五個具有補血、補氣的方劑,利用血球凝集試驗法以及直接螢光染色法,分別測定實驗 動物之抗體力價, T 淋巴細胞與其亞群細胞,協助性 T 細胞╱抑制性 T 細胞 (Th/Ts) 比 值之變化。 實驗結果, 顯示補益方劑對正常實驗老鼠並無明顯影響, 但治療組 (以 prednisolone 引發免疫低下 ) 中以四物湯、人參養榮湯顯示具有免疫提升功能,所呈現效 能與免疫增強劑 levamisole 相似, 對免疫低下之預防則普遍有提升作用, 且效果較 levamisole 強。 我們期望藉由本研究一方面闡明補益方劑之免疫增強作用,另方面則能藉 此開發出更有效之中藥免疫增強劑。 |
英文摘要 | The traditional Chinese medicine have been known involved in immunological effect. The traditional Chinese medical science has held by "disease is confrontation between vital energy of the human body and pathogenic factors", therefore disease cause is usually decided by genuine energy which not balance. Generally, Chinese medicine therapy rule is "to strengthen the patient's resistance and dispel the invading pathogenic factors (扶正袪邪 ) in order to action on imune disease". We chose 5 Tonic Chinese prescriptions: Shen Ling Bai-Zhu San, Si Jun Zi Tang, Si Wu Tang, Qing Shu Yi, Ren-Shen Yang Rong Tang, Which are used in the trcatment of deficiency of many abnomral genuine energy functional activities by Chinese medical doctor. Combination of direct agglutination test micro-hemagglutination method and direct fluorescent antibody test Fascan Flow Cyto-mete, to detect Antibody titer, T lymphocyte and subclass of T cells (helper T cell, suppressor T cell) and Th/Ts ratio. The result have found (1) that those prescription was not affected to mice on normal condition, (2) it had good immuno-enhance activity when prednisolone induced immunosuppressed condition as well as immunopoteniator (levamisole) results by giving three different prescription of Si Wu Tang and Ren-Shen Yang Rong Tang, (3) in precaution test we found more than half tonic medicine prescription had better activity than levamisole treatment. We were hoping to understand the immunity system by these prescripition and to develop a good immunopotentiator in immuno-suppressed disease. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。