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題名 | Distribution of Free and Liposome-encapsulated Norfloxacin in Rat Skin Following Topical Administratin=游離態以及微脂粒包覆之Norfloxacin經局部投與後在大白鼠皮內的分佈情形 |
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作者 | 林恆弘; 許立人; 黃葆芳; 蔡義弘; Lin, Hung-hong; Hsu, Li-ren; Huang, Bao-fang; Tsai, Yi-hung; |
期刊 | 嘉南學報 |
出版日期 | 19971100 |
卷期 | 23 1997.11[民86.11] |
頁次 | 頁34-41 |
分類號 | 418.1 |
語文 | eng |
關鍵詞 | 游離態; 微脂粒; 大白鼠皮內; Norfloxacin; Liposomes; Transdermal delivery; Rat skin; |
英文摘要 | 本研究主要是經由大白鼠之體外與體內實驗,探討微脂粒包覆對norfloxacin經 皮吸收的影響。由體外實驗的結果發現,norfloxacin採用微脂粒包覆後可增加藥物在角質 層的負載量;同時,微脂粒藥物自角質層的排除速率亦較游離型的藥物緩慢,而組成微脂粒 的磷脂質中對藥物在角質層內滯留能力的大小依序是 DSPC>DPPC>DMPC。 體內實驗八小時所 得到的藥物血中濃度曲線下面積,與體外實驗之皮膚通透量間,存在著良好的相關性;而局 部使用 norfloxacin 微脂粒製劑與口服藥物水溶液比較之下, 微脂粒包覆藥物在大白鼠皮 可產生較高且持續的藥物含量,因此,微脂粒處方在作為局部藥物輸移系統上展現了極大之潛 力。 a good correlation was observed between the AUC in vivo and the flux for permeation experimens in vitro. However, topical applications of liposomal preparations of norfloxacin result in higher and longlasting amount of drug in the rat skin as compare to oral administration of norfloxacin solution. The liposomal formulations show great potential as a topical drug delivery system. |
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