頁籤選單縮合
題名 | Reverse Micelles as Life-Mimicking Systems=以逆向微脂粒模擬生命系統 |
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作者姓名(中文) | 張固剛; 黃德美; 洪慧芝; | 書刊名 | Proceedings of the National Science Council : Part B, Life Science |
卷期 | 24:3 2000.07[民89.07] |
頁次 | 頁89-100 |
分類號 | 360 |
關鍵詞 | 逆向微脂粒; 生命系統; Micellar enzymology; Membranous protein; Detergent; Surfactant; Alkaline phosphatase; Detoxification; GST; Enzyme model; Enzyme mechanism; |
語文 | 英文(English) |
英文摘要 | In this review, we attempt to demonstrate that reverse micelles are simple artificial systems that mimic many life systems from cell division to the creation of an enzyme catalytic mechanism. For a membranous enzyme like placental alkaline phosphatase, the kinetic properties observed in reverse micelles might represent those found under physiological conditions. The reverse micellar system, consisting of a positively charged surfactant, mimics a detoxification enzyme glutathione transferase. We propose a novel island-in-oil-lake reverse micellar model for the glutathione transferase that can account for almost all the catalytic properties of this enzyme. Reverse micelles may provide an excellent model system in investigating the reaction mechanism of other detoxification enzymes. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。