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題名 | 五味子中Schizandrin及Gomisin A定量及抗肝損傷之研究=Quantitative Analysis of Schizandrin and Gomisin a and Liver Protective Activity of Schisandrae Frutctus |
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作 者 | 江睿玲; 謝明村; 周泰廷; 郭槐秋; 張永勳; | 書刊名 | 中醫藥雜誌 |
卷期 | 8:3 1997.09[民86.09] |
頁次 | 頁155-164 |
分類號 | 414.5 |
關鍵詞 | 五味子; 定量分析; 抗肝損傷; Schsandrae fructus; Schizandrin; Gomisin A; HPLC; Liver protection; |
語文 | 中文(Chinese) |
中文摘要 | 五味子為中醫常用藥材,其成分與藥理作用均被廣泛研究。本研究以水、50%酒 精及95%酒精三種不同溶媒分別抽取五味子並以高效液相層析分析,比較得知以95%酒精抽 取五味子其中schizandrin及gomisin A含量最高,50%酒精抽取液次之,以水抽取者含量 最低。由抗肝損傷藥理試驗顯示95%酒精抽取物亦具有較高的生物活性,水抽出物活性低, 可提供五味子萃取及入藥時的參考。 此外,急性毒性試驗結果亦發現五味子水、50%酒精及95%酒精三種抽取物對鼷鼠之半 數致死劑量(LD□)分別為1.60 g/kg,1.75 g/kg及1.00 g/kg,可見五味子具有一定的毒 性,使用時應注意其劑量之控制。 |
英文摘要 | Schisandrae Fructus, the fruit of Schisandra chinensis (Turcz.) Baill is a traditional Chinese medicine. Its constituents and pharmacological activities had been extensively studied. Schisandrae Fructus was extracted by water. 50% alcohol and 95% alcohol respectively and were quantitatively analyzed by high performance liquid chromatography (HPLC). The content of schizandrin and gomisin A in 95% alcohol extracts was highest followed by 50% alcohol extract and water extract. The 95% alcohol extracts also showed higher liver protective activity. The acute toxicity LD□ was 1.0-1.6g/kg (oral; 95% confidence 0.67-2.43g/kg) of Schisandrae Fructus extract. |
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