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頁籤選單縮合
題名 | Antiplatelet drugs Induce Apoptosis in Cultured Cancer Cells=抗血小板藥物引起培養癌細胞細胞凋零死亡 |
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作者姓名(中文) | 陳偉熹; 尹莘玲; 張永義; 藍旻瑜; 徐雪瑩; 劉家壽; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷期 | 13:10 1997.10[民86.10] |
頁次 | 頁589-597 |
分類號 | 418.2321 |
關鍵詞 | 抗血小板藥物; 癌細胞; 凋零; Apoptosis; Antiplatelet drug; Cancer; |
語文 | 英文(English) |
中文摘要 | 為了解抗血小板藥物是否擁有抗癌作用,本文測定5種抗血小板藥物在6種培養癌細胞(Hep 3B肝癌,U87-MG星狀細胞癌,PC-34攝護腺癌,HeLa子宮頸癌,HL-60前血癌及K-562血癌)是否會引起細胞凋零作用。Acetylsalicyate及flunarizine對6種細胞皆無作用。除HL-60及K-562外,pentoxifylline,dipyridamole及ticlopidine,則引起 時間及濃度依賴性細胞凋零作用。Adriamycin可同時引起這6種癌細胞細胞凋零,但若adriamycin同時合併pentoxifylline,dipyridamole或ticlopidine,卻並未增加細胞凋零比例。因此,確實擁有細胞凋零作用,這對癌症病人可做輔助治療。 |
英文摘要 | In order to understand If antiplatelet drugs possess direct antineoplastic property, we tested the apoptotic effect of 5 popularly marketed antiplatelet drugs in Taiwan in 6 cultured cancer cell lines (Hep 3B epatocarcinoma, U87-MG malignant glioma, PC-3 prostate adenocarcinoma, HeLa cervical adenocarcinoma, HL-60 preleukemia and K-562 chronic myelogenous leukemia). While acetylsalicylate and flunarizine exerted no effect on these cancer cells, pentoxifyline (PTX), dipyridamole (DYA) and ticlopidine hydrochloride (T. HCl) displayed a time and dose-dependent apoptotic effect on them except for HL-60 and K-562 cells. PTX induced apoptosis in U87-MG, Hep 3B and HeLa cells, DYA in HeLa cells, while T. HCI in U87-MG, Hep 3B, PC-3 and HeLa cells. Adriamycin also provoked apoptotic effect in all 6 cell lines but neither PTX, DYA nor T. HCl acted synergy with adriamycin to HeLa cells, implicating that they may share a similar pathway for inducing apoptosis. Therefore, our results show that the antiplatelet drugs do posses antineoplastic property in vitro. A co-administration of antiplatelet drugs is noteworthy for an alternative adjunctive therapy in cancer patients. |
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