查詢結果分析
相關文獻
- p53--控制細胞生長及凋零的重要因子
- Fas and CD45RO Antigen Expression on Peripheral Blood Mononuclear Cells in Patients with Ankylosing Spondylitis: A Comparison with Autoimmune Diseases
- A Taiwanese Isolate of Chicken Anemia Virus Induces Apoptosis in the in Vitro Culture Cells
- Effects of Norepinephrine on Apoptosis in Rat Neonatal Cardiomyocytes
- 中藥複方治療過敏性鼻炎對嗜中性白血球細胞凋零調控影響之研究
- Survivin Expression in Cardiac Myxoma
- 草果(Amomum Tsao-ko)
- 間歇性低壓低氧後細胞的變化
頁籤選單縮合
題 名 | p53--控制細胞生長及凋零的重要因子=p53--The Main Control Factor of Cell Proliferation and Apoptosis |
---|---|
作 者 | 韓鴻志; 樂國柱; | 書刊名 | 秀傳醫學雜誌 |
卷 期 | 1:4 1999.07[民88.07] |
頁 次 | 頁175-178 |
分類號 | 415.138 |
關鍵詞 | 細胞凋零; 細胞環; p53; p21; p53; Apoptosis; p21; Cell cycle; |
語 文 | 中文(Chinese) |
中文摘要 | p53是控制細胞增殖主要的因素之一,其可抑制細胞的生長和轉形。一個普遍的觀 念,認為p53扮演著“基因庫的守衛者”的角色,藉由阻止帶有損傷的DNA之細胞進行增殖, 而可暫時的將細胞環之進行停止,直到損傷被修復;另外,又可永久的藉由將受損的細胞推向 不可逆的細胞凋零機轉,導致細胞死亡。近來的研究顯示:p53的活化基因p21□為一 cyclin-kinase的抑制者,可調控p53依賴性的細胞環停止,故當DNA受損導致細胞計劃性 死亡,需要轉錄活化p53,卻不需活化p21□。本文之目的,即在闡明p53與p21□在控制癌 細胞的增殖,與腫瘤的細胞凋零上,所扮演的角色。 。 |
英文摘要 | P53 is one of the major factors controlling cell proliferation, suppressing both growth and transformation of cells. A prevalent idea is that p53 acts as "guardian of the genome" by preventing cells bearing damaged DNA from proliferating, either temporarily, by arresting the cell division cycle until damage is repaired, or permanently, by pushing the damaged cell down an irreversible apoptotic pathway of cell suicide. Current research highlights the action of a p53-activated gene, p21 Δ,which encodes a cyclin-kinase inhibitor important in mediating p53-dependent cellcycle arrest, while programmed cell death in response to DNA damage requires transcriptionally active p53 but not activation of p21Δ.This review will examine the roles of p53 and p21Δin controlling cancer cell proliferation and tumor apoptosis. apoptosis. |
本系統中英文摘要資訊取自各篇刊載內容。