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| 題 名 | Effects of Antiglaucoma Drugs and Corticosteroids on the Cellular Glucose Uptakein Cultured Porcine Corneal Endothelial Cells=抗青光眼藥及類固醇眼藥對體外培養之豬角膜內皮細胞葡萄糖攝取的影響 |
|---|---|
| 作 者 | 吳國揚; 洪秀貞; 馮濟敏; 鍾怡梅; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
| 卷 期 | 13:8 1997.08[民86.08] |
| 頁 次 | 頁480-486 |
| 分類號 | 418.2323 |
| 關鍵詞 | 抗青光眼藥; 類固醇眼藥; 體外培養; 豬角膜內皮細胞葡萄糖; 2-deoxyglucose uptake; Corneal endothelial cells; |
| 語 文 | 英文(English) |
| 中文摘要 | 在本實驗中主要是探討臨床上多種不同的抗青光眼藥及類固醇眼藥對於豬角膜內皮細胞對糖份攝取的影響。當角膜內皮細胞對糖份之攝取受影響時將會直接影響內皮細胞將水分送出角膜的能力，體外培養的豬角膜內皮細胞經過不同抗青光眼藥及類固醇眼藥處理100分鐘之後，細胞對糖份的攝取能力有不同的變化，當細胞經過藥物的處理後糖份攝取與控制組比較時發現，經betaxolol處理過的細胞由3.1% (1.6mM)，181% (0.16mM) 到158% (0.016mM)，經timolol處理的細胞由93% (0.79mM)，227% (0.079mM) 到151% (0.079mM)，經carteolol處理的細胞由141% (3.4mM)，180%(0.34mM)到97% (0.034mM)，levobunolol處理的細胞由80% (1.5mM)，98% (0.15mM) 到90% (0.015mM)，經dipivefrin處理的細胞由116% (0.2mM)，176% (0.02mM) 到108% (0.002mM)，以及經pilocarpine處理的細胞其細胞對糖份攝取的變化則由115% (9.6mM)，210% (0.96mM) 到210% (0.096mM)。細胞在經過fluorometholone處理過，細胞糖份攝取量的改變則由160% (0.26mM)，139% (0.026mM) 到107% (0.0026mM)，在dexamethasone改變量則是85% (0.25mM)，117 (0.025mM) 到109% (0.0025mM)，在betamethasone的變化量由95% (0.25mM)，96% (0.025mM) 到99% (0.0025mM)，由以上結果顯示除了高濃度的betaxolol，levobunolol及dexamethasone之外，其餘的抗青光眼藥及類固醇眼藥不會降低角膜內皮細胞對糖份攝取的能力。 |
| 英文摘要 | In this study, various commercially used antiglaucoma drugs and corticosteroids were investigated in their effects on porcine corneal endothellal cells especially in cellular glucose uptake. Cellular glucose uptake directly affects the pumping efficiency in corneal endothelial cells. Following the cells’ treatment with various antiglaucoma eyedrops for 100 mm, the 3H-2-deoxyglucose uptake in cultured porcine corneal endothelial cells was affected by betaxolol from 3.1% (1.6 mM), 181 % (0.16 mM)to 158% (0.016mM), by timolol from 93% (0.79 mM), 227% (0.079 mM) to 151% (0.0079 mM), by carteolol from 141% (3.4 mM), 180% (0.34 mM) to 97% (0.034 mM), by levobunolol from 80% (1.5 mM), 98% (0.15 mM) to 90% (0.015 mM), by dipivefrin from 116% (0.2 mM), 176% (0.02 mM) to 108% (0.002 mM) and by pilocarpine from 115% (9.6 mM), 210% (0.96 mM) to 210% (0.096 mM) when the cells were compared with a control medium. In the presence of various corticosteroids, the glucose uptake in corneal endothelial cells was affected by fluorometholone from 160 % (0.26 mM), 139% (0.026 mM) to 107% (0.0026 mM), by dexamethasone from 85% (0.25 mM), 117% (0.025 mM) to 109% (0.0025 mM) and by betamethasone from 95% (0.25 mM), 96% (0.025 mM) to 99% (0.0025 mM). These results show that the commercial eyedrops of antiglaucoma drugs and corticosteroids will not decrease the cellular glucose uptake in cultured porcine corneal endothelial cells except when incubated with high concentrations of betaxolol, levobunolol and dexamethasone. |
本系統中英文摘要資訊取自各篇刊載內容。