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頁籤選單縮合
題名 | 口腔癌的惡性變性過程=Malignant Transformation of Oral Cancer |
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作者姓名(中文) | 楊政杰; 高壽延; 張哲壽; | 書刊名 | 牙醫學雜誌 |
卷期 | 17:2 1997.06[民86.06] |
頁次 | 頁105-110 |
分類號 | 416.94 |
關鍵詞 | 惡性變性; 細胞週期; Malignant transformation; Cell cycle; |
語文 | 中文(Chinese) |
中文摘要 | 自從十九世紀著名的病理學家 Virchow,將癌症界定成因細胞不正常分裂所造成 的「細胞疾病」以來,針對癌症的研究便著重於癌細胞的生物特性上,因而開啟了癌症生物 學之門,而缺乏在臨床上存在於正常細胞及腫瘤間可供辨識的專一性差異,是發展出專一性 抗癌療法的主要障礙,欲治癒腫瘤首要必須使所有腫瘤的幹細胞失去其產生子代細胞的能力 ,對於口腔癌亦然。因此透過對於細胞週期的過程及其控制機轉的瞭解,進而瞭解整個癌症 在惡性變性過程中的所有細節,將有助於更早期的診斷出口腔癌甚或發展出更有效的癌症療 法。 |
英文摘要 | Since the eminent pathologist, Virchow, declared in 19th century that cancer was a cellular disease resulting from abnormal proliferation of a cell, the research of cancer has been focused on the biological properties of cancer cell. And this resulted in the development of cancer biology. The absence of specific identifiable differences between normal and malignant cells is a major barrier that has limited the development of specific anticancer therapy. Tumor cure requires the treatment to cause all tumor stem cells to lose their ability to generate progeny that can regrow the tumor. It is the same as oral cancer. So through the understanding of the process and control mechanism of cell cycle, we can realize much more how the tumor cell transformed. And this will help us to develop early diagnostic methods or even more effective therapies of cancer. |
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