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題名 | 細胞凋亡在子宮頸癌治療上可能的應用=Apoptosis as a Novel Alternative for the Treatment of Human Cervical Cancer |
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作者 | 劉鴻文; 鄧素蘋; 葉青華; 鄭光輝; 易序芳; 張麗姿; | 書刊名 | 醫學研究 |
卷期 | 17:6 1997.05[民86.05] |
頁次 | 頁335-343 |
分類號 | 417.2832 |
關鍵詞 | 子宮頸癌; 細胞凋亡; 細胞週期; 視網酸; Cervical cancer; Differentiation; Apoptosis; Retinoic acid; TPA; |
語文 | 中文(Chinese) |
中文摘要 | 本文主要探討最近成為學術研究焦點的細胞凋亡(apoptosis),可否在子宮頸癌治療上,提供一具有潛力之途徑。惡性腫瘤發生時,經常與去分化有關;因此治療子宮頸癌的另一途徑可能為誘導癌細胞進行再分化,或回歸正常之細胞週期。視網酸(retinoic acid)可執行多項生物功能,包括胚胎之發育、防止非表皮細胞之角質化、以及透過視網醇類化合物X體受(RXR)以和一些生長因子之受體產生交互作用。而細胞分化趨化物12-O-tetradecanoyl-13-phobol-acetate(TPA)為phorbol ester之一種,可刺激細胞趨向分化、增生或死亡。本實驗室最近的研究結果顯示視網酸和TPA皆可促使人類子宮頸癌細胞進行細胞分化;並進一步促使其發生細胞凋亡。這些結果顯示細胞凋亡在子宮頸癌治療上,或許是一具有潛力之途徑;而其機轉則有待進一步之研究。 |
英文摘要 | Carcinogenesis is commonly associated with progression toward de differentiation, so one of alternative treatments may be the activation of the mechanisms which induce re-differentiation and/or apoptosis in tumor cells. Retionic acid (RA) is known to exert a variety of biological functions, including embryonic development, protecting non-epidermal epithelia from keratinization, and interacting with some growth factors through retinoid X receptors (RXR). A differentiation promoting reagent, 12-O-tetradecanoy 1 phorbol-13-acetate(TPA), induces the differentiation of human leukemia HL-60 cells into macrophage. HL-60 cells revealed apoptosis when terminally differentiated. In recent studies, we found that RA and TPA may alter differentiation status and induce apoptosis in human cervical cancer cell lines, which suggests that apoptosis may be a novel alternative for the treatment of cervical cancer. |
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