查詢結果分析
來源資料
相關文獻
- 活血化瘀中藥對人體白血球功能的影響
- Nitro変-L-Arginine Methyl Ester Decreases Minimum Alveolar Concentration of Isoflurane and Reduces Brain Nitric Oxide Synthase Activity in Rats
- 長期阻斷內生性一氧化氮對血壓的影響:正常鼠與高血壓鼠間的比較
- 使用吸入性一氧化氮(NO)治療成人呼吸窘迫症(ARDS):利?或弊?
- Altering Sphingomyelin Signaling in Vessels from Stroke-prone Spontaneously Hypertensive Rats
- 運動對一氧化氮合成酶基因表現的影響
- 一氧化氮與上呼吸道
- 敗血性休克的致病機轉和治療之探討:生理、生化、藥物和藥理的角度
- 聚醣類誘導魚隻產生一氧化氮
- 木本樹種淨化臭氧與二氧化氮能力之評估(3)
頁籤選單縮合
題名 | 活血化瘀中藥對人體白血球功能的影響 |
---|---|
作者 | 洪傳岳; | 書刊名 | 中醫藥年報 |
卷期 | 15:2 1997.05[民86.05] |
頁次 | 頁101-112 |
分類號 | 414.5 |
關鍵詞 | 三亞油酸; 環狀GMP; 氧化氮; 蛋白激酸C; 過氧陰離子; 多形核白血球; Trilinolein; Cyclic GMP; Nitric oxide; Protein kinase C; Superoxide anion; Polymorphonuclear leukocytes; |
語文 | 中文(Chinese) |
中文摘要 | 三亞油酸是一種三酸甘油脂,是中藥三七之活性成分之一,其甘油的三個酯化位 置之脂肪酸都是亞油酸, 近來被報告可經由 nitric oxide - cyclic GMP 途徑而產生抗血 小板活性,本研究中,我們也將針對三亞油酸在人類多形核白血球產生 cyclic GMP 方面之 效應做研討, 結果顯示三亞油酸與多形核白血球及應 10 分鐘之後,在 0.lnM 到 lO μ M 之濃度範圍, 可增加 cyclic GMP 之形成, 以 methylene blue (l μ M )、 NG- monomethyl-L-arginine (l μ M) 或 d-sphingosine (10 μ M) 做前處理,都可降低三亞 油酸的效應,此外,我們亦發現 xanthine oxidase 可阻斷三亞油酸的效應。中藥三七之活 性成份,三亞油酸之所以能增加多形核白血球之 cyclic GMP,可能部分藉由 nitric oxide 的形成,部分活化 protein kinase C,同時,superoxide anion 的增加可阻斷三亞油酸誘 導 cyclic GMP 增加。中藥與白血球功能之關係,值得進一步之探討。 |
英文摘要 | Trilinolein, a triacylglycerol with linoleic acid as the only type of fatty acid residue in all three esterified positions of glycerol, was recently found to be an active ingredient in Panax Notoginseng. It was reported to have an antiplatelet effect mediated through stimulating nitric oxide and cyclic GMP formation. In this study, the effect of trilinolein on cyclic GMP formation in human polymorphonuclear leukocytes was investigated. Trilinolein at concentrations ranged from 0.1nM to 10 μ M increased cyclic GMP formation after 10min incubation with polymorphonuclear leukocytes. Pretreated with 1 μ M methylene blue, 1 μ MNG-monomethyl-L-arginine or 10 μ M d-sphingosine attenuated the stimulatory effect of trilinolein on cyclic GMP formation. Besides, we found that the stimulatory effect of trilinolein on cyclic GMP was abolished by xanthine oxidase which increased superoxide anion. We concluded that trilinolein increased cyclic GMP in polymorphonuclear leukocytes paryly by stimulating nitric oxide formation and partly by activating protein kinase C, and an increase in superoxide anion abolished the trilinolein-induced increase in cyclic GMP. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。