查詢結果分析
來源資料
相關文獻
- 加味小柴胡湯對慢性C型肝炎之臨床療效評估
- 慢性C型肝炎之治療
- Interferon-α Therapy for Children with Chronic Hepatitis C
- 慢性C型肝炎與肝癌關係
- 臺灣肝臟病系列(40):慢性C型肝炎之抗病毒治療
- Expression of Interferon Alpha/Beta Receptor Genes in Peripheral Blood Cells of Chronic Hepatitis C Patients
- Probable Reinfection with Hepatitis C Virus in a Chronic Hepatitis C Patient with a Sustained Response to Combination Therapy
- Prolonged Interferon Treatment after Combination Interferon and Ribavirin Therapy in Patients with Chronic Hepatitis C: A Clinical Trial of Interferon Relapsers and Non-Responders
- Apoptosis in Viral Hepatitis B and C
- 重新建構針扎事件通報系統的處置流程
頁籤選單縮合
題 名 | 加味小柴胡湯對慢性C型肝炎之臨床療效評估 |
---|---|
作 者 | 李純青; 湯惠玲; 李采娟; 莊榮豐; 林昭庚; | 書刊名 | 中醫藥年報 |
卷 期 | 15:1 1997.05[民86.05] |
頁 次 | 頁145-177 |
分類號 | 414.5 |
關鍵詞 | 慢性C型肝炎; 加味小柴胡湯; Chronic hepatitis c; Jia wei xiao chai hu tang; PCR; |
語 文 | 中文(Chinese) |
中文摘要 | C型肝炎之治療, 目前尚無一極有效的方法,而使用干擾素日α-II之療效仍未及 l/2,且使用時問長,價格昂貴。 本項研究即參考中醫之傳統肝炎治療原則,採用中藥或干 擾素或安慰劑之治療,並評估其療效,期能找出治療時間最短及及金錢負擔最輕之良法。由 八十二年至八十五年,本研究採用現代之檢驗技術, 包括 EIA、PCR、ALT、Sona 等以確定 C 型肝炎病患, 從中國醫藥學院附設醫院肝膽科門診病人中,篩選合乎「慢度性 C 型肝炎 」診斯標準之志願者作為研究對象, 隨機分為三組計 6O 人, 患者並以 ANOVA、Kruskal- Wallis test、HSD test 等統計方法分析其 ALT、AST、 HCV RNA、HCV Ab 及臨床症以評估 其療效及副作用。結果顯示干擾治療之效果較加味小柴胡湯或安慰劑為佳。但加味小柴胡湯 亦能降低 ALT、AST 值, 改善慢性 C 型肝炎臨床症狀,未出現注射干擾素之副作用且價便 宜,而安慰劑組則對降低 ALT、AST 值及改善臨床症狀療效不明顯,因而適當加減小柴胡湯 ,使其增強清除 HCV Ab 功能或調節免疫能力,將是一個值得發展的途徑。 |
英文摘要 | For years, it has been of much interest and value to many identify methodology for curing chronical C hepatitis, for this disease is likely to turn into cirrhosis or hepatoma due to low expectation of curability. Of all known medication for chronical hepatitis C, the injection of interferone has been shown to be the most effective. The outcome, however, is still not satisfactory. Besides, it is costly and has side-effects. This study seeks the curing power of "jia wei xiao chai hu Tang" on chronical C type hepatitis. This study also assesses the level of ALT, AST,HCV RNA, HCV Ab, and the clinic symptom, and compares the side effects and costs in order to identify the possibility of a substitute to interferone. The test group for this study was selected from the volunteered patients, who were most qualified, for China Medical college Hospital. Twenty patients as the test group were given "jai wei xiao chai hu Tang" or ~injected interferone for six months. Another twenty patients as the control group were given placebo for the same period. The results, analyzed through ANOVA.Kruskal-Wallis test. HSD test, show that "jai wei xiao Chai hu Tang" is able to improve clinical symptom of chronical C hepatitis. The side effects occurred in applying interferone do not appear in the medication of "jai wei Xiao Chi hu Tang" under studies. Besides, it reduces the level of ALT and AST, and it costs less. However, the effectiveness of interferone in the reduction of the level of ALT and AST to normal range and the effect of clearing-up of HCV RNA is the best than the jia wei xiao chai hu tang or placebo. This report shows that although Supplemented Minor Bupleurum Decoction (jia wei xiao chai hu tang) cannot substitute interferon,it does nevertheless have it clinical effect.If it is to be developed,agents that address the virus and eliminate HCV RNA function must be incorporated into it. Further research is necessary if a new Chinese medical approach to the treatment of chronic Hepatitis C is to be created. |
本系統中英文摘要資訊取自各篇刊載內容。