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頁籤選單縮合
| 題 名 | Apoptosis in Viral Hepatitis B and C=細胞凋亡與B型與C型病毒性肝炎 |
|---|---|
| 作 者 | 戴達英; 蔡順隆; | 書刊名 | 長庚醫學 |
| 卷 期 | 24:5 2001.05[民90.05] |
| 頁 次 | 頁285-293 |
| 分類號 | 415.5332 |
| 關鍵詞 | 細胞凋亡; 慢性B型肝炎; 慢性C型肝炎; 腫瘤壞死因子; 腫瘤壞死因子受體; Apoptosis; Hepatitis B virus; Hepatitis C virus; Tumor necrosis factor; Tumor necrosis factor receptor; |
| 語 文 | 英文(English) |
| 英文摘要 | Tumor necrosis facor (TNF) and TNF receptors (TNFR) are members of the growing TNF ligand and receptor families known to be involved in apoptosis, viral pathogenesis and immune regulation. The present report will focus on the role of apoptosis in the pathogenesis of viral hepatitis B and C. Although TNF was reported years ago to modulate viral infections, recent findings on the molecular pathways involved in TNFR signaling have allowed a better understanding of the molecular interactions between cellular and viral factors within the infected cell. The interactions of viral proteins with intracellular components downstream of the TNFR have highlighted at the molecular level that viruses can manipulate the cellular machinery to escape the immune surveillance and to favor spread infection. We will review here the mechanism of apoptosis and the role of viral proteins that regulate apoptosis in viral hepatitis B and C. (Chang Gung Med J 2001;24:285-93) |
本系統中英文摘要資訊取自各篇刊載內容。