查詢結果分析
來源資料
相關文獻
- 定喘湯、小青龍湯對過敏原激發無麻醉天竺鼠立即性與遲發性反應呼吸道阻力與發炎細胞之影響
- 麻杏石甘湯與其減石膏對過敏原激發氣喘天竺鼠呼吸道阻力與發炎細胞之研究
- 川芎嗪對氣喘動物模式治療之探討
- 麻杏石甘湯與其減甘草對過敏原激發氣喘天竺鼠呼吸道阻力與發炎細胞之研究
- Airway Hyperreactivity Modulated by Immunotherapy with Denatured Ovalbumin in Ovalbumin-Sensitized Guinea Pigs
- 過敏性氣喘
- 麻杏甘石湯對塵蟍誘發氣喘天竺鼠之影響
- 各年齡層氣喘病人食物過敏率與過敏程度之研究
- The Anti-Inflammatory Effect of a Long-Acting Theophylline (Unidur) in Patients with Bronchial Asthma
- 腎氣丸對塵蟍激發喘天竺鼠呼吸道發炎與免疫之影響
頁籤選單縮合
題 名 | 定喘湯、小青龍湯對過敏原激發無麻醉天竺鼠立即性與遲發性反應呼吸道阻力與發炎細胞之影響 |
---|---|
作 者 | 高尚德; | 書刊名 | 中醫藥年報 |
卷 期 | 15:1 1997.05[民86.05] |
頁 次 | 頁75-99 |
分類號 | 414.5 |
關鍵詞 | 氣喘; 呼吸道阻力; 氣管肺泡沖洗液分析; Asthma; Respiratory resistance; Bronchoalveolar lavage; |
語 文 | 中文(Chinese) |
中文摘要 | 過敏性氣喘是臨床上常兒的疾病,其流行率、發作頻率與嚴重度近年來逐漸提高 。而在中醫古典醫籍中,對於氣喘的病機、症狀早已有詳細的記載,並累積了豐富的臨床經 驗與治療方劑,但許多治療機轉卻仍未明瞭。本研究則是利用氣喘動物模式來探討常被用來 治療氣喘的方劑 - 定喘湯小青龍湯的治病機轉。定喘湯組 216 隻體重 350 至 450 克重雄 性無特殊病原之 Dunkin-Hartley 天竺鼠,以隨機方式分為六小組,每小組 36 隻,其分組 為 (一 ) 實驗組一:激發前三十分鐘給藥。(二 ) 實驗組二:激發後第五小時給藥。(三 ) 實驗組三,激發前二十四小時及二小給藥。(四 ) 實驗組四,致敏前三天起‥每天連續給藥 至激發前 30 分鐘。(五 ) 對照組:依序誘導激發,不給藥。(六 ) 基準組:不致敏、不激 發。 小青龍湯組用天竺鼠 180 隻,隨機分組如下:(一 ) 實驗組一:激發前 30 分鐘給予 ,予小青龍湯。 (二 ) 實驗組二:激發後 5 小時給予小青龍湯。(三 ) 實驗組三,激發前 30 分鐘與激發後 5 小時都給予小青龍湯。(四 ) 實驗組四:致敏開始至激發前,每天給予 一次小青龍湯。(五 ) 對照組,致敏、激發但不治療。(六 ) 基準組:致敏、不激發、不治 療。實驗方法是以霧化之 1% 卵白蛋白讓天竺鼠吸入,每天一次,每次 10 分鐘,連續讓天 竺鼠吸入八天, 然後休息七天, 再於實驗開始第十六天,讓天竺鼠吸入霧化之卵白蛋白 5 分鐘以激發氣喘發作, 定喘湯用 3% 卵白蛋白, 小青龍湯用 1% 卵白蛋白,於激發後第 5 分鐘、1、2、4、6、8、12、24、48、72 小時測量天竺鼠之呼吸道阻力,並於激發後第 1、 6、24、48、72 小時進行支氣管肺泡沖洗液分析及肺部病理組織切片, 再使用 ANOVA 統計 分析方法分析小青龍湯對呼吸道阻力與發炎細胞的影響。定喘湯研究結果顯示,實驗組一、 二與對照組比較在激發後 12 小時前能有意義降低氣喘天竺鼠呼吸道阻力,實驗組二、四則 顯著降低立即性與遲發性氣喘反應之呼吸道阻力。對支氣管肺泡沖洗液的分析顯示實驗組一 在 6 小時、實驗組三、四在 1、6 小時之多形核白血球顯著低於對照組,而實驗組一在 12 、24 小時,實驗組三在 12、24、48 小時, 實驗組四在 12、24、48、72 小時之嗜伊紅性 白血球皆顯著低於對照組,肺部病理切片檢查並顯示各實驗組發炎紳胞的浸潤與平滑肌收縮 的程度有降低的趨勢。綜合以上結果得知定喘陽能有效的降低非麻醉性卵白蛋白致敏氣喘天 竺鼠立即與遲發性反應的呼吸道阻力與發炎細胞。其可能的機轉是,b2- 類腎上腺素刺激劑 作用、抗發炎作用及穩定初級作用細胞的作用。小青龍湯實驗結果顯示實驗組二 65 呼吸道 阻力於各時間點與對照組比較均無顯著差異,實驗組一、三、四與對照組比較則顯示能顯著 降低立即性與遲發性氣喘反應的呼吸道阻力。對支氣管肺泡沖洗液的分析顯示實驗組一、三 於 6 小時與 24 小時時嗜伊紅性白血球的比率顯著低於控制組, 實驗組二僅於 24 小時顯 著低於控制組,實驗組四則於各時間點均顯著低於控制組。肺部病理切片檢查則顯示各實驗 組發炎細胞的浸潤與平滑肌收縮的程度有降低的趨勢。綜合以上結果得知,小青龍陽能有效 治療氣喘的立即性與遲發性反應,並能減少局部的發炎細胞浸潤,因此我們推測小青龍湯除 了直接鬆弛呼吸道平滑肌外,尚具有某程度的抗發炎功效。 |
英文摘要 | Allergic asthma is a common disease. The prevalence of this disease increased rapidly and its seriousness becomes worse and worse in recent years. There were detailed descriptions about the pathologic mechanisms, symptoms, clinical experiences and therapeutic prescriptions of asthma in the books of traditional Chinese medicine. However, many therapeutic mechanisms are still unclear. The asthmatic animal model was used in this study to investigate the therapeutic mechanisms of Ding-Chuan Tang and Xiao-Qing-Long-Tang those were used often in clinics. The animals used in Ding-Chuan-Tang's study, 216 male Dunkin-Hertley guinea pigs were randomized equally into six groups: (1)Expreiment group one-pretreated 30 minutes before challenge (2) Experiment group two-treated 5 hours after challenge (3) Experiment group three-treated once daily, three days before sensitization till the day of challenge (5) Control froup-sensitized and challenged, no treatment (6) standard group-no sensitization, challenge or treatment. One hundred and eighty (SPF) male Dunkin-Hartley guinea pigs, weighting 350-450 grams, were randomly allocated into six groups in, Xiao-Qing-Long-Tang's study: (1) Experiment group one pretreated 30 minutes before challenge. (2)Experiment group two treated 5 hours after challenge. (3)Experiment group three - treated 30 minutes before challenge and 5 hours after challenge. (4)Experiment group four - treated once daily from the day of sensitization to the day of challenge. (S)Control group - were sensitized and challenged without treatment.,(6) Standard group - without sensitization, challenge or treatment. The guinea pigs were sensitized by inhalation of 1% aerosolized ovalbumin once a day for 10 minutes, for 8 days. They were challenged to induce the asthmatic responses by inhalation of 3% aeroselized ovalbumin in Ding-Chuan-Tang group and 1% aerosolized ovalbumin in Xiao-Qing-Long-Tang group respectively for 5 minutes on day 16. The airway resistance was examined at time points: 5 minutes, 1, 2, 4, 6, 8, 12, 24, 48 and 72 hours after challenge. The bronchoalveolar lavage and.pathologic biopsy were proceeded at time points: 1, 6, 24, 48 and 72 hours after challenge. Finally, the data were analyzed by one-way ANOVA. Ding-Chuan-Tang group: the results revealed that all the P/ V ratios(reprensented for airway resistance) in control group signifcantly increased over than "2". In control group, the neutrophil rates significantly increased in late asthmatic reaction. For pathologic biopsy, the pulmonary inflammatory cells infiltration and the constriction of airway smooth muscles were reduced in' all experiment group on and two significantly decreased when compared with control group in the eraly asthmatic reaction showed the "therapeutic effect" of Ding-Chuan- Tang. The P/V ratios, neutrophil rates, and eosinophil rates of experiment group in the early three significantly decreased when compared with control group in the early and late asthmatic reactions showed the "prevention of sensitization" of Ding-Chuan- Tang. The P/V ratios, neutrophil rates and eosinophilrate of experiment group four also significantly decreased when compared with control group in the early and late asthmatic reactions showed the "prevention of anti-sensitization" of Ding-Chuan- Tang. In summary, Ding-Chuan-Tang was effective to relieve the early and late asthmatic reactions and reduce the pulmonary inflammatory cells infilration. the possible efficient mechanisms could be ~through b2-adrenoceptor agonist, some degree of anti-inflammation and primary effector cells stablization. Xiao-aing-Long-Tang group: The results showed that the airway resistance was not significantly different between experiment group two and control group. The airway resistance of experiment group one, three and four significantly decreased compared with control group in the early and late asthmatic reactions. For bronchoalveolar lavage analysis, the percentages of eosinophil of experiment group one and three significantly decreased compared with control group at 6 and 24 hours, but significant difference was observed only at 24 hours for experiment group two. The percentages of eosinophil of experiment group four significantly decreased at each time point. For pathologic biopsy, the local infiltration of inflammatory cells and the constriction of airway smooth muscles were reduced in all experiment group. In summary, Xiao-Qing-Long-Tang was' useful to relieve the early and late asthmatic reactions and reduce the local infiltration of inflammatory cells. Therefore, we suggested the therapeutic mechanisms of Xiao-Qing-Long-Tang were through airway smooth muscle relaxation and some degree of antiinflammation. |
本系統中英文摘要資訊取自各篇刊載內容。