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題 名 | 麻杏石甘湯與其減甘草對過敏原激發氣喘天竺鼠呼吸道阻力與發炎細胞之研究=Effects of Ma-Xing-Shi-Gan-Tang and Its Minus Redix Gly-Cyrrhizae on Bronchoconstriction and Airway Leukocyte Infiltration after Allergen Challenge of Asthmatic Guinea Pigs |
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作 者 | 葉宗仁; 高尚德; 葉豐次; 林昭庚; | 書刊名 | 中國醫藥學院雜誌 |
卷 期 | 7:1 1998.03[民87.03] |
頁 次 | 頁83-92 |
分類號 | 414.5 |
關鍵詞 | 麻杏石甘湯; 氣喘; 呼吸道阻力; 氣管肺泡沖洗液; Dermatophagoides pteronyssinus; Ma-xing-shi-gan tang; Bronchoalveolar lavage; Respiratory resistance; |
語 文 | 中文(Chinese) |
中文摘要 | 麻杏石甘湯為我國漢朝張仲景所著〞傷寒論〞中之方劑,用於解熱、平喘、鎮咳 。本研究為證實麻杏石甘湯與其減甘草對氣喘之影響及甘草在本方中所扮演之角色,以氣喘 動物模式, 進行本實驗。 本研究以無特別致病原, 體重 350 至 550 公克的雄性 Dunkin-Hartley 白色天竺鼠 120 隻為實驗動物。隨機分組如下:實驗組 -A (麻杏石甘湯 , MXSG ) 30 隻、實驗組 -B (麻杏石甘湯減甘草,MXS ) 30 隻、對照組 30 隻、基準 組 30 隻; 於 Day 0 及 Day 7 各予每隻天竺鼠施打( I.P. ) Dermatophagoides Pteronyssinus 蛋白質溶液, 休息 14 天,以利誘導天竺鼠對 D.Pteronyssinus 產生致敏 現象,並於 Day 21 作激發試驗。 實驗後第 5 分鐘、1、2、4、6、8、12、24、48、72 小 時分別測其呼吸道阻力及氣管肺泡沖洗液分析。實驗結果,得知麻杏石甘湯與麻杏石甘湯減 甘草治療氣喘均有療效,其可緩解氣喘天竺鼠立即性反應期之呼吸道阻力、降低呼吸道炎症 。然後者由於缺少甘草之配伍,對呼吸道阻力及多形核白血球濃度降低的效果,麻杏石甘湯 減甘草比麻杏石甘湯差;同時支氣管中之發炎細胞浸潤程度,麻杏石甘湯和麻杏石甘湯減甘 草之作用亦有顯著的差異性,這顯示麻杏石甘湯中之甘草在此方劑中的重要性,而在臨床上 仍應使用麻杏石甘湯,較具治療氣喘之價值;至於其詳細機轉有待進一步研究。 |
英文摘要 | In an attempt to establish an animal model for the study of asthma, Dermatophagoides pteronyssinus was used as an allergen to sensitize Ginea pigs. In this study, the changes in respiratory resistance and inflammatory cell infiltration of the respiratory tract in sensitized guinea pigs were evaluated before and after the administration of Ma-Xng-Shi-Gan Tang (MXSG) by bodyplethysmography bronchoalveolar lavage. Pathological changes of the bronchus were assesed to evaluate Mxs's effects (MXSG minus Glycyrrhiza) on respiratory resistance and inflammation of the respiratory tract. The results are summarized as follows: (1) MXSG and MXS lowered the respiratory resistance significantly in the early phase of the effect of MXSG was stronger than MXS. (2) BOth MXSG and MXS lowered the percentage of neutrophils in bronchoalveolar lavage fluid significantly in the early phase of the experiment. However, the effect of MXSG was much stronger than MXS. (3) MXSG and MXS had no effect on eosinophil count. (4) Both MXSG and MXS inhibit infiltration of the bronchus in the early phase of experiment. In summary, both MXSG and MXS lowered the respiratory resistance as well as the percentage of neutrophils in the early phase of experimentally induced asthma. Glycyrrhiza which is capable to relax respiratory muscle and to inhibit inflammation, may play an important role in the enhancement of the MXSG effect. |
本系統中英文摘要資訊取自各篇刊載內容。