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題名 | 以脈診分析原理研究六味地黃丸之作用 |
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作者 | 王唯工; | 書刊名 | 中醫藥年報 |
卷期 | 15:3 1997.05[民86.05] |
頁次 | 頁147-169 |
分類號 | 414.5 |
關鍵詞 | 脈診分析; 共振理論; 六味地黃丸; 熟地; 山茱; 丹皮; 茯苓; 澤寫; Pulse analysis; Resonance theory; Liow wei di huang wan; Rehmannia glutinosa; Cornus officinalis; Paeonia suffruticosa; Poria cocos and alisma plantogo-aquatica var; Oriental; |
語文 | 中文(Chinese) |
中文摘要 | 在此計劃中我們以基於血液波共振理論發展之脈診分析方法研究六味地黃丸及其 五味主成份 (熟地、山茱、丹皮、茯苓、及澤瀉 ) 之作用,及各成份之交互影響。 以期探 討中藥之歸經理論,和中藥藥方之藥理。在動物實驗,我們將各藥物之水溶粗萃物注入老鼠 腹部後,測量老鼠尾動脈脈波頻譜。發現六味地黃丸為一藥效極為緩和以減少 C5,C6,C7( 收陽氣 ),降心火 (CO),以增加 C1,C2,C3 (肝、腎、脾 ) 之補陰之方。 它增加低頻相 關經絡及器官肝 C1,腎 C2, 脾 C3,之血流量,而降低高頻相關經絡及器官, C4 肺、C5 胃、C6 膽、C7 膀胱,之血流量。同時它也降低血臟荷頻譜之 DC(CO) 值。所有我們所研究 的五味主成份一致增益腎、脾 (C2、C3),對陽氣則各有增減或與其各自特殊藥效相關。 它 們皆會增加通往腎 C2 及脾 C3 之血流量,澤瀉會微幅降低 CO、C5、C6 及 C7 但增加第一 諧波比值 (C1);茯苓降低 C1、C4、C5 及 C6; 熟地及丹皮降低 C4、C5、C6 及 C7;山茱 增加 C4 但降低 C5,C6 及 C7。人體實驗口服六味地黃丸在我們觀察的期間 150 分鐘內, 只見氣 (C3,C6,C9) 之增加並未見其補腎功能。橈動脈之脈波頻譜圍繞峰值 C3 及 C6 之 C1,C3,C5,C6,C7 及 C9 平均值都明顯增加;往腎之血流量,C2 明顯降低。補氣成份可 能較易於在口服狀況下吸收作用,未來長期多次劑量觀察實驗設計,應可更完整了解藥物之 作用進程。 |
英文摘要 | The pulse analysis method was used in studing the traditional Chinese formula Liow Wei Di Huang Wan as well as five its main components (Rehmannia glutinosa, Cornus officinalis, Paeonia Suffruticosa, Poria cocos and Alisma plantogo-aquatica var. oriental). Based on our new developed resonance theory, we were trying to understanding the working mechanism and the mutual reactions of these meridian related herbs. In the animal study, the hot water herbal extracts were injected intraperitoneally into rats and the pressure pulse spectrum at the caudate artery was measured. The study indicates that the Liow Wei Di Huang Wang mildly increased the blood to the lower frequency decided meridians and their related organs, the liver C1, the kidney C2 and the spleen C3, but decreasing the blood to the higher frequency decidied organ, the lung C4, the stomach C5, the Gall bladder C6, and the Bladder C7. It decreases the heart load CO also. All the five herb components we studied increased the blood to the Kidney C2 and the spleen C3; but their effects on the higher frequency decided organs varied differently which may related to their specific drug functions. Alisma plantogo-aquatica var. oriental decreased the C0, C5, C6, C7 but increased the C1; Poria cocos decreased C1, C4, C5, C6. Rehmannia glutinosa, Paeonia suffruticosa decreased C4, C5, C6, C7. Cornus officinalis increased C4 but decreased C5, C6, C7. For human subject fed with the formula extract, the pulse on the radial artery was examined. In the observation period (150mins), the average values of the harmonic proportions of C1, C3, C5, C6, C7 and C9 were significantly increased around the peak values C3, C6. However, the formula did not increase the blood to the kidney; C2 was decreased. The ingradients which increases the "Chi" (C3, C6, C9 realted) may be much easier to be absorbed and functioned under oral intake condition. |
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