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題名 | 改變過敏原特異性第二型幫助性T細胞免疫反應--過敏病的明日療法=Immune Intervention of Development of Th2 Cells--A Therapeutic Approach of Tomorrow for Allergic Disease |
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作者 | 謝貴雄; Hsieh, Kue-hsiung; |
期刊 | 中華民國小兒科醫學會雜誌 |
出版日期 | 19970400 |
卷期 | 38:增刊A 民86.04 |
頁次 | 頁7-9 |
分類號 | 415.69 |
語文 | chi |
關鍵詞 | 過敏原; T細胞; 免疫反應; 過敏病; |
英文摘要 | Th2 cells are the types 2 antigen-activated T help-er cells that secret e a number of unique cytokines that are involved in the immunopathogenesis of bronchial asthma and ohter allergic disease. Th2 cells secrete IL-4 and IL-13 that promote the IgE production by B cells, and IL-5 that induces the differentiation and activation and prolonged survival of eosinophils and recruitments of eosinophils to the inflamed airways. Th2 cells only secrete a small amount or even do not produce IFN- γ at all. INF- γ is the cytokine that antagonizes IL-4 and IL-13 action. There are now a number of methods that can re-direct both in vitro and in vivo the helper T cell func-tion from Th2 response to Th1 response, and therefor provide new modalities for the treatment of allergic diseases in the near future : 1. Induction of nonresponsiveness or anergy of antigen-specific Th2 cells 2. Redirect the Th2 immune response to Th1 immune response 3. Suppress the differentian of Th2 Cells by IL-4R and IL-13R mAb. 4. Naked DNA-allergen vaccines. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。