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題名 | Augmented Secretion of Tumor Necrosis Factor-Alpha during Sepsis Following Splenectomy in Mice=脾臟切除鼷鼠在敗血症時血中含有較高之腫瘤壞死因子濃度 |
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作者 | 張財旺; 李榮順; 林炳文; 張敏政; | 書刊名 | 中華民國外科醫學會雜誌 |
卷期 | 30:3 民86.05-06 |
頁次 | 頁149-154 |
分類號 | 415.121 |
關鍵詞 | 脾臟切除; 鼷鼠; 敗血症; 腫瘤壞死因子; TNF-α; Splenectomy; Cecal ligation and puncture; Sepsis; |
語文 | 英文(English) |
中文摘要 | 本研究計劃旨在探討脾臟切除對敗血症引致腫瘤壞死因子(TNF-α)分 泌之影響。實驗中,C3H/HeN鼷鼠先經脾臟切除(實驗組)或假性脾臟除切(對照 組),三週後,再接受盲腸結紮及穿孔術(CLP)以產生敗血症。結果,兩組動物血 中之TNF-α值,約在CPL後2小時,可用ELISA方法測出,而在4小時左右到達尖 峰值。比較兩組動物TNF-α之尖峰值 (實驗組:380.5±59.3pg/mL,mean±SEM, n=10;對照組:117.9±31.8pg/mL, |
英文摘要 | This research project was purported to investigate the effect of splenectomyon sepsis-induced tumor necrosis factor-alpha (TNF-α) secretion. C3H/HeNmice used in the experiment were subjected to splenectomy (SP group)and sham operation (SS group) three weeks prior to sepsis. Cecal ligationand puncture (CLP) methods were used to produce sepsis. In both splenectomized and sham-splenectomized groups, serum TNF-α levels became detectable by ELISA methods 2 hours after CLP and reached the peak 4 hours(SP group: 380.5±59.3 pg/mL, mean±SEM, n=10; SS group: 117.9±31.8 pg/mL, mean±SEM, n=10) after CLP. The peak levels of TNF-α concentrationsduring sepsis in splenectomized group were more than three times higherthan that in sham-splenectomized group (p< 0.005). In addition, highersurvival rates from CLP-induced sepsis were correlated in splenectomizedgroup than in sham-splenectomized group. In summary, these results showthat splenectomy is associated with higher serum levels of TNF-α in animalssubjected to CLP-induced sepsis, suggesting the negative regulatory effectof the spleen on TNF-α secretion in sepsis. Moreover, higher TNF-α levelsafter splenectomy may confer protective effect to the host in defendingsepsis resulting from CLP. |
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