查詢結果分析
來源資料
相關文獻
- Augmented Secretion of Tumor Necrosis Factor-Alpha during Sepsis Following Splenectomy in Mice
- Interleukin-6 (IL-6), Tumor Necrosis Factor α(TNFα), and C-reactive Protein (CRP) Serum Levels in Newborns with Sepsis
- 粗製巴斯德桿菌D型毒素誘發腫瘤壞死因子-α產生與豬萎縮性鼻炎關係之探討
- Detection of Tumor Necrosis Factor-α and Receptors in the Serum and Synovial Fluid of Patients With Rheumatoid Arthritis and Osteoarthritis
- 第一型介白質受體對抗劑和腫瘤壞死因子結合蛋白對去卵巢後骨質減少的效果
- 導管引起之敗血症
- 敗血症(Sepsis)致病機轉及治療
- 敗血性休克的致病機轉和治療之探討:生理、生化、藥物和藥理的角度
- Beneficial Effects of Tetramethylpyrazine, an Active Constituent of Chinese Herbs, on Rats with Endotoxemia
- 氣腫性腎盂腎炎--10病例分析和文獻回顧
頁籤選單縮合
題 名 | Augmented Secretion of Tumor Necrosis Factor-Alpha during Sepsis Following Splenectomy in Mice=脾臟切除鼷鼠在敗血症時血中含有較高之腫瘤壞死因子濃度 |
---|---|
作 者 | 張財旺; 李榮順; 林炳文; 張敏政; | 書刊名 | 中華民國外科醫學會雜誌 |
卷 期 | 30:3 民86.05-06 |
頁 次 | 頁149-154 |
分類號 | 415.121 |
關鍵詞 | 脾臟切除; 鼷鼠; 敗血症; 腫瘤壞死因子; TNF-α; Splenectomy; Cecal ligation and puncture; Sepsis; |
語 文 | 英文(English) |
中文摘要 | 本研究計劃旨在探討脾臟切除對敗血症引致腫瘤壞死因子(TNF-α)分 泌之影響。實驗中,C3H/HeN鼷鼠先經脾臟切除(實驗組)或假性脾臟除切(對照 組),三週後,再接受盲腸結紮及穿孔術(CLP)以產生敗血症。結果,兩組動物血 中之TNF-α值,約在CPL後2小時,可用ELISA方法測出,而在4小時左右到達尖 峰值。比較兩組動物TNF-α之尖峰值 (實驗組:380.5±59.3pg/mL,mean±SEM, n=10;對照組:117.9±31.8pg/mL, |
英文摘要 | This research project was purported to investigate the effect of splenectomyon sepsis-induced tumor necrosis factor-alpha (TNF-α) secretion. C3H/HeNmice used in the experiment were subjected to splenectomy (SP group)and sham operation (SS group) three weeks prior to sepsis. Cecal ligationand puncture (CLP) methods were used to produce sepsis. In both splenectomized and sham-splenectomized groups, serum TNF-α levels became detectable by ELISA methods 2 hours after CLP and reached the peak 4 hours(SP group: 380.5±59.3 pg/mL, mean±SEM, n=10; SS group: 117.9±31.8 pg/mL, mean±SEM, n=10) after CLP. The peak levels of TNF-α concentrationsduring sepsis in splenectomized group were more than three times higherthan that in sham-splenectomized group (p< 0.005). In addition, highersurvival rates from CLP-induced sepsis were correlated in splenectomizedgroup than in sham-splenectomized group. In summary, these results showthat splenectomy is associated with higher serum levels of TNF-α in animalssubjected to CLP-induced sepsis, suggesting the negative regulatory effectof the spleen on TNF-α secretion in sepsis. Moreover, higher TNF-α levelsafter splenectomy may confer protective effect to the host in defendingsepsis resulting from CLP. |
本系統中英文摘要資訊取自各篇刊載內容。